tris(benzyloxycarbonyl)-L-arginyl-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine

Base Information

• Chemical Name: tris(benzyloxycarbonyl)-L-arginyl-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine
• CAS No.: 151012-19-0
• Molecular Formula: C₄₅H₅₁ClN₆O₁₁
• Molecular Weight: 887.387

Synonyms:tris(benzyloxycarbonyl)-L-arginyl-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine

Chemical Property of tris(benzyloxycarbonyl)-L-arginyl-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine

Chemical Property:

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Technology Process of tris(benzyloxycarbonyl)-L-arginyl-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine

There total 6 articles about tris(benzyloxycarbonyl)-L-arginyl-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

tris(benzyloxycarbonyl)-L-arginyl-Nα-methyl-Nε-(2-chlorobenzyloxycarbonyl)-L-lysine tert-butyl ester (151012-18-9) → tris(benzyloxycarbonyl)-L-arginyl-Nα-methyl-Nε-(2-chlorobenzyloxycarbonyl)-L-lysine (151012-19-0)

Guidance literature:

With trifluoroacetic acid; In dichloromethane; for 0.666667h;

DOI:10.1021/jm9508043

Reference yield:

C35H40N4O10 → tris(benzyloxycarbonyl)-L-arginyl-Nα-methyl-Nε-(2-chlorobenzyloxycarbonyl)-L-lysine (151012-19-0)

Guidance literature:

Multi-step reaction with 2 steps

1: N-methylmorpholine / CH₂Cl₂ / 5 h / Ambient temperature

2: 87 percent / TFA / CH₂Cl₂ / 0.67 h

With 4-methyl-morpholine; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jm9508043

Reference yield:

Nε-(2-chlorobenzyloxycarbonyl)-Nα-methyllysine methyl ester → tris(benzyloxycarbonyl)-L-arginyl-Nα-methyl-Nε-(2-chlorobenzyloxycarbonyl)-L-lysine (151012-19-0)

Guidance literature:

Multi-step reaction with 5 steps

1: 54 percent / CH₂Cl₂ / 4 h

2: 92 percent / 1N NaOH / methanol / 0 - 20 °C

3: 1.) H₂SO₄ / 1.) dioxane, 10 min, 2.) dioxane, 6 h

4: N-methylmorpholine / CH₂Cl₂ / 5 h / Ambient temperature

5: 87 percent / TFA / CH₂Cl₂ / 0.67 h

With 4-methyl-morpholine; sodium hydroxide; sulfuric acid; trifluoroacetic acid; In methanol; dichloromethane;

DOI:10.1021/jm9508043

upstream raw materials:

tris(benzyloxycarbonyl)-L-arginyl-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine tert-butyl ester

(S)-6-(2-Chloro-benzyloxycarbonylamino)-2-methylamino-hexanoic acid tert-butyl ester

Boc-[N-MeLys(ClZ)]-OH

N^α-(tert-butoxycarbonyl)-N^α-methyl-N^ε-(2-chlorobenzyloxycarbonyl)-L-lysine methyl ester

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