isopropyl 2-amino-4-(3,5-bis(trifluoromethyl)phenyl)butanoate

Base Information

Chemical Name:isopropyl 2-amino-4-(3,5-bis(trifluoromethyl)phenyl)butanoate
CAS No.:1361394-42-4
Molecular Formula:C₁₅H₁₇F₆NO₂
Molecular Weight:357.296
Hs Code.:

Synonyms:isopropyl 2-amino-4-(3,5-bis(trifluoromethyl)phenyl)butanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of isopropyl 2-amino-4-(3,5-bis(trifluoromethyl)phenyl)butanoate

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Technology Process of isopropyl 2-amino-4-(3,5-bis(trifluoromethyl)phenyl)butanoate

There total 7 articles about isopropyl 2-amino-4-(3,5-bis(trifluoromethyl)phenyl)butanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1361394-41-3
tert-butyl 4-(3,5-bis(trifluoromethyl)phenyl)-1-hydroxybutan-2-ylcarbamate

: 1361394-42-4
isopropyl 2-amino-4-(3,5-bis(trifluoromethyl)phenyl)butanoate

Guidance literature:: Multi-step reaction with 3 steps

1: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

2: dichloromethane / 20 °C / Inert atmosphere

3: thionyl chloride / 0 °C / Inert atmosphere; Reflux

With dipyridinium dichromate; thionyl chloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol300063t

Reference yield:

: 1361394-40-2
(E)-4-(3,5-bis(trifluoromethyl)styryl)-3-(4-nitrophenylsulfonyl)oxazolidin-2-one

: 1361394-42-4
isopropyl 2-amino-4-(3,5-bis(trifluoromethyl)phenyl)butanoate

Guidance literature:: Multi-step reaction with 7 steps

1: potassium carbonate; thiophenol / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

2: palladium 10% on activated carbon; hydrogen / ethanol / 10 h / 20 °C / Inert atmosphere

3: lithium hydroxide / ethanol; water / 2 h / Inert atmosphere; Reflux

4: dichloromethane / 0 - 20 °C / Inert atmosphere

5: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

6: dichloromethane / 20 °C / Inert atmosphere

7: thionyl chloride / 0 °C / Inert atmosphere; Reflux

With dipyridinium dichromate; thionyl chloride; palladium 10% on activated carbon; hydrogen; potassium carbonate; thiophenol; lithium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol300063t

Reference yield:

: 1388828-47-4
C₁₃H₉F₆NO₂

: 1361394-42-4
isopropyl 2-amino-4-(3,5-bis(trifluoromethyl)phenyl)butanoate

Guidance literature:: Multi-step reaction with 6 steps

1: palladium 10% on activated carbon; hydrogen / ethanol / 10 h / 20 °C / Inert atmosphere

2: lithium hydroxide / ethanol; water / 2 h / Inert atmosphere; Reflux

3: dichloromethane / 0 - 20 °C / Inert atmosphere

4: dipyridinium dichromate / N,N-dimethyl-formamide / 20 °C / Inert atmosphere

5: dichloromethane / 20 °C / Inert atmosphere

6: thionyl chloride / 0 °C / Inert atmosphere; Reflux

With dipyridinium dichromate; thionyl chloride; palladium 10% on activated carbon; hydrogen; lithium hydroxide; In ethanol; dichloromethane; water; N,N-dimethyl-formamide;
DOI:10.1021/ol300063t