4-(4-Methoxy-2-nitro-phenylamino)-2,5-dihydro-thiophene-3-carbonitrile

Base Information

• Chemical Name: 4-(4-Methoxy-2-nitro-phenylamino)-2,5-dihydro-thiophene-3-carbonitrile
• CAS No.: 74137-91-0
• Molecular Formula: C₁₂H₁₁N₃O₃S
• Molecular Weight: 277.304
• Mol file: 74137-91-0.mol

Synonyms:4-(4-Methoxy-2-nitro-phenylamino)-2,5-dihydro-thiophene-3-carbonitrile

Chemical Property of 4-(4-Methoxy-2-nitro-phenylamino)-2,5-dihydro-thiophene-3-carbonitrile

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 4-(4-Methoxy-2-nitro-phenylamino)-2,5-dihydro-thiophene-3-carbonitrile

There total 1 articles about 4-(4-Methoxy-2-nitro-phenylamino)-2,5-dihydro-thiophene-3-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

4-oxotetrahydrothiophene-3-carbonitrile (16563-14-7) + 4-methoxy-2-nitroaniline (96-96-8) → 4-(4-Methoxy-2-nitro-phenylamino)-2,5-dihydro-thiophene-3-carbonitrile (74137-91-0)

Guidance literature:

With boron trifluoride diethyl etherate; In toluene; for 4h; Heating;

DOI:10.1021/jm00182a014

Reference yield: 88.0%

4-(4-Methoxy-2-nitro-phenylamino)-2,5-dihydro-thiophene-3-carbonitrile (74137-91-0) → 4-(4-Methoxy-2-nitro-phenylamino)-thiophene-3-carbonitrile (74137-95-4)

Guidance literature:

With chloranil; In xylene; for 2h; Heating;

DOI:10.1021/jm00182a014

Reference yield:

4-(4-Methoxy-2-nitro-phenylamino)-2,5-dihydro-thiophene-3-carbonitrile (74137-91-0) → 4-(2-Amino-4-methoxy-phenylamino)-thiophene-3-carbonitrile

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / chloranil / xylene / 2 h / Heating

2: 100 percent / hydrogen / 10percent Pd/C / ethanol; ethyl acetate / 2 h / 3102.9 Torr / Ambient temperature

With hydrogen; chloranil; palladium on activated charcoal; In ethanol; ethyl acetate; xylene;

DOI:10.1021/jm00182a014

upstream raw materials:

4-oxotetrahydrothiophene-3-carbonitrile

4-methoxy-2-nitroaniline

Downstream raw materials:

4-(4-Methoxy-2-nitro-phenylamino)-thiophene-3-carbonitrile