C₃₃H₃₉ClN₄O₃

Base Information

Chemical Name:C₃₃H₃₉ClN₄O₃
CAS No.:1021913-08-5
Molecular Formula:C₃₃H₃₉ClN₄O₃
Molecular Weight:575.151
Hs Code.:

C<sub>33</sub>H<sub>39</sub>ClN<sub>4</sub>O<sub>3</sub>

Synonyms:C₃₃H₃₉ClN₄O₃

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Chemical Property of C₃₃H₃₉ClN₄O₃

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Technology Process of C₃₃H₃₉ClN₄O₃

There total 7 articles about C₃₃H₃₉ClN₄O₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1021913-06-3
tert-butyl (2R)-2-(2-{[3-bromo-7-chloro-6-(1-methyl-1H-pyrazol-4-yl)quinolin-4-yl]oxy}ethyl)piperidine-1-carboxylate

: 172975-69-8
3,5-dimethylphenyl boronic acid

: 1021913-08-5
C₃₃H₃₉ClN₄O₃

Guidance literature:: With caesium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In tetrahydrofuran; water; at 120 ℃; for 0.166667h; microwave irradiation;

Reference yield:

: 1021913-07-4
7-chloro-4-hydroxy-6-iodoquinoline-3-carboxylic acid

: 1021913-08-5
C₃₃H₃₉ClN₄O₃

Guidance literature:: Multi-step reaction with 5 steps

1.1: diphenylether / 1 h / 250 °C

2.1: N-Bromosuccinimide; acetic acid / 2 h / 60 °C

3.1: triphenylphosphine / tetrahydrofuran / 0.05 h / 20 °C / Sonication

3.2: 0.83 h / Sonication

4.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 0.25 h / 80 °C / Microwave irradiation

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 0.17 h / 120 °C / Microwave irradiation

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; acetic acid; triphenylphosphine; In tetrahydrofuran; diphenylether; water; 3.1: Mitsunobu reaction / 3.2: Mitsunobu reaction;
DOI:10.1021/jm101501b

Reference yield:

: 1021913-01-8
ethyl 7-chloro-4-hydroxy-6-iodoquinoline-3-carboxylate

: 1021913-08-5
C₃₃H₃₉ClN₄O₃

Guidance literature:: Multi-step reaction with 6 steps

1.1: sodium hydroxide / water / Reflux

2.1: diphenylether / 1 h / 250 °C

3.1: N-Bromosuccinimide; acetic acid / 2 h / 60 °C

4.1: triphenylphosphine / tetrahydrofuran / 0.05 h / 20 °C / Sonication

4.2: 0.83 h / Sonication

5.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 0.25 h / 80 °C / Microwave irradiation

6.1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate / tetrahydrofuran; water / 0.17 h / 120 °C / Microwave irradiation

With N-Bromosuccinimide; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; caesium carbonate; acetic acid; triphenylphosphine; sodium hydroxide; In tetrahydrofuran; diphenylether; water; 4.1: Mitsunobu reaction / 4.2: Mitsunobu reaction;
DOI:10.1021/jm101501b