Technology Process of benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine
There total 7 articles about benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate;
palladium diacetate;
In
tetrahydrofuran;
at 20 - 90 ℃;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: n-butyllithium; diisopropylamine; N,N-dimethyl-formamide / tetrahydrofuran; hexanes / 1.75 h / -78 - 0 °C
1.2: 25 h / 0 - 20 °C
2.1: ammonia / methanol; water / 4 h / 0 - 20 °C
3.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 20 °C
4.1: 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / palladium diacetate / tetrahydrofuran / 20 - 90 °C
With
n-butyllithium; 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; ammonia; potassium carbonate; caesium carbonate; diisopropylamine; N,N-dimethyl-formamide;
palladium diacetate;
In
tetrahydrofuran; methanol; hexanes; DMF (N,N-dimethyl-formamide); water;
- Guidance literature:
-
Multi-step reaction with 2 steps
1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 20 °C
2: 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / palladium diacetate / tetrahydrofuran / 20 - 90 °C
With
2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; potassium carbonate; caesium carbonate;
palladium diacetate;
In
tetrahydrofuran; DMF (N,N-dimethyl-formamide);