benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine

Base Information

Chemical Name:benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine
CAS No.:808138-61-6
Molecular Formula:C₂₉H₂₅FN₆
Molecular Weight:476.556
Hs Code.:

Synonyms:benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine

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Chemical Property of benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine

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Technology Process of benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine

There total 7 articles about benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1013-88-3
Benzophenone imine

: 808138-60-5
5-chloro-2-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-3-propyl-pyrazine

: 808138-61-6
benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine

Guidance literature:: With 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate; palladium diacetate; In tetrahydrofuran; at 20 - 90 ℃;

Reference yield:

: 407-22-7
2-fluoro-6-methylpyridine

: 808138-61-6
benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium; diisopropylamine; N,N-dimethyl-formamide / tetrahydrofuran; hexanes / 1.75 h / -78 - 0 °C

1.2: 25 h / 0 - 20 °C

2.1: ammonia / methanol; water / 4 h / 0 - 20 °C

3.1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 20 °C

4.1: 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / palladium diacetate / tetrahydrofuran / 20 - 90 °C

With n-butyllithium; 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; ammonia; potassium carbonate; caesium carbonate; diisopropylamine; N,N-dimethyl-formamide; palladium diacetate; In tetrahydrofuran; methanol; hexanes; DMF (N,N-dimethyl-formamide); water;

Reference yield:

: 438564-53-5
2-Fluoro-6-(1H-imidazol-2-yl)-pyridine

: 808138-61-6
benzhydrylidene-{5-[2-(6-fluoro-pyridin-2-yl)-imidazol-1-ylmethyl]-6-propyl-pyrazin-2-yl}-amine

Guidance literature:: Multi-step reaction with 2 steps

1: potassium carbonate / DMF (N,N-dimethyl-formamide) / 20 °C

2: 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; caesium carbonate / palladium diacetate / tetrahydrofuran / 20 - 90 °C

With 2,2'-bis(diphenylphosphino)-1,1'-binaphthyl; potassium carbonate; caesium carbonate; palladium diacetate; In tetrahydrofuran; DMF (N,N-dimethyl-formamide);