(5-bromo-2-chlorobenzyloxy)triisopropylsilane

Base Information

Chemical Name:(5-bromo-2-chlorobenzyloxy)triisopropylsilane
CAS No.:1225430-36-3
Molecular Formula:C₁₆H₂₆BrClOSi
Molecular Weight:377.824
Hs Code.:

Synonyms:(5-bromo-2-chlorobenzyloxy)triisopropylsilane

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Chemical Property of (5-bromo-2-chlorobenzyloxy)triisopropylsilane

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Technology Process of (5-bromo-2-chlorobenzyloxy)triisopropylsilane

There total 3 articles about (5-bromo-2-chlorobenzyloxy)triisopropylsilane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 13154-24-0
triisopropylsilyl chloride

: 149965-40-2
5-bromo-2-chlorobenzyl alcohol

: 1225430-36-3
(5-bromo-2-chlorobenzyloxy)triisopropylsilane

Guidance literature:: With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃; for 15h; Inert atmosphere;

Reference yield:

: 13154-24-0
triisopropylsilyl chloride

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 1225430-36-3
(5-bromo-2-chlorobenzyloxy)triisopropylsilane

Guidance literature:: 5-bromo-2-chlorobenzoic acid; With potassium carbonate; methyl iodide; In N,N-dimethyl-formamide; at 20 ℃; for 3h;

With lithium aluminium tetrahydride; In toluene; at 20 ℃; for 2h;

triisopropylsilyl chloride; With 1H-imidazole; dmap; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bmc.2013.08.067

Reference yield:

: 21739-92-4
5-bromo-2-chlorobenzoic acid

: 1225430-36-3
(5-bromo-2-chlorobenzyloxy)triisopropylsilane

Guidance literature:: Multi-step reaction with 2 steps

1.1: borane dimethyl sulfide complex / tetrahydrofuran / 15 h / 0 - 20 °C / Inert atmosphere

1.2: 0 °C / Inert atmosphere

2.1: dmap; 1H-imidazole / N,N-dimethyl-formamide / 15 h / 20 °C / Inert atmosphere

With 1H-imidazole; dmap; borane dimethyl sulfide complex; In tetrahydrofuran; N,N-dimethyl-formamide;