(S)-methyl 2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanoate

Base Information

Chemical Name:(S)-methyl 2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanoate
CAS No.:1624283-74-4
Molecular Formula:C₂₁H₂₀N₂O₃
Molecular Weight:348.401
Hs Code.:

Synonyms:(S)-methyl 2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanoate

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Chemical Property of (S)-methyl 2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanoate

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Technology Process of (S)-methyl 2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanoate

There total 1 articles about (S)-methyl 2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: (R)-methyl 3-phenyl-2-(trifluoromethylsulfonyl)propanoate

: 74990-54-8
4-anilino-2-oxo-1,2-dihydropyridine

: 1624283-74-4
(S)-methyl 2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanoate

Guidance literature:: With sodium hydride; In N,N-dimethyl-formamide; at 0 - 20 ℃; for 13h; Reflux;
DOI:10.1002/cmdc.201402075

Reference yield: 97.0%

: 1624283-74-4
(S)-methyl 2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanoate

: 1624283-87-9
(S)-2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanoic acid

Guidance literature:: With lithium hydroxide; In methanol; water; at 0 - 20 ℃; for 4h;
DOI:10.1002/cmdc.201402075

Reference yield:

: 1624283-74-4
(S)-methyl 2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanoate

: 1624283-47-1
(R)-1-{(S)-2-[2-oxo-4-(phenylamino)pyridin-1(2H)-yl]-3-phenylpropanamido}-3-methylbutylboronic acid

Guidance literature:: Multi-step reaction with 3 steps

1: lithium hydroxide / methanol; water / 4 h / 0 - 20 °C

2: benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine / dichloromethane / 3 h / -15 - 20 °C

3: hydrogenchloride; Dihydroxy-isobutyl-boran / methanol; hexane; water / 18 h / 20 °C

With hydrogenchloride; Dihydroxy-isobutyl-boran; benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; lithium hydroxide; In methanol; hexane; dichloromethane; water;
DOI:10.1002/cmdc.201402075