3-<2-(dimethylamino)ethoxy>-6,7-dihydro-8-phenyl-9-(hydroxyphenyl)-5H-benzocycloheptene

Base Information

Chemical Name:3-<2-(dimethylamino)ethoxy>-6,7-dihydro-8-phenyl-9-(hydroxyphenyl)-5H-benzocycloheptene
CAS No.:113748-79-1
Molecular Formula:C₂₇H₂₉NO₂
Molecular Weight:399.533
Hs Code.:

Synonyms:3-<2-(dimethylamino)ethoxy>-6,7-dihydro-8-phenyl-9-(hydroxyphenyl)-5H-benzocycloheptene

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Chemical Property of 3-<2-(dimethylamino)ethoxy>-6,7-dihydro-8-phenyl-9-(hydroxyphenyl)-5H-benzocycloheptene

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Technology Process of 3-<2-(dimethylamino)ethoxy>-6,7-dihydro-8-phenyl-9-(hydroxyphenyl)-5H-benzocycloheptene

There total 6 articles about 3-<2-(dimethylamino)ethoxy>-6,7-dihydro-8-phenyl-9-(hydroxyphenyl)-5H-benzocycloheptene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28557-00-8
phenylzinc chloride

: 113748-79-1
3-<2-(dimethylamino)ethoxy>-6,7-dihydro-8-phenyl-9-(hydroxyphenyl)-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

2: 83 percent / HBr / acetic acid / 5 h / Heating

3: 83 percent / n-Bu₄N⁽¹⁺⁾*HSO₄^(1-), aq. NaOH / 1 h / Heating

4: 2.) NaOMe / 1) ethanol, reflux, 20 h; 2) DMF, 40 deg C, 1 h

With sodium hydroxide; hydrogen bromide; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; cyclohexane; acetic acid;
DOI:10.1021/jm00402a005

Reference yield:

: 113748-80-4
3-methoxy-6,7-dihydro-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

: 113748-79-1
3-<2-(dimethylamino)ethoxy>-6,7-dihydro-8-phenyl-9-(hydroxyphenyl)-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 5 steps

1: 82 percent / pyridine hydrobromide perbromide / CH₂Cl₂ / 3 h

2: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

3: 83 percent / HBr / acetic acid / 5 h / Heating

4: 83 percent / n-Bu₄N⁽¹⁺⁾*HSO₄^(1-), aq. NaOH / 1 h / Heating

5: 2.) NaOMe / 1) ethanol, reflux, 20 h; 2) DMF, 40 deg C, 1 h

With sodium hydroxide; hydrogen bromide; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; pyridinium hydrobromide perbromide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; dichloromethane; cyclohexane; acetic acid;
DOI:10.1021/jm00402a005

Reference yield:

: 113748-81-5
3-methoxy-6,7-dihydro-8-bromo-9-<4-<2,3,5,6-tetrafluoro-4-(trifluoromethyl)phenoxy>phenyl>-5H-benzocycloheptene

: 113748-79-1
3-<2-(dimethylamino)ethoxy>-6,7-dihydro-8-phenyl-9-(hydroxyphenyl)-5H-benzocycloheptene

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / Pd(PPh₃)4 / diethyl ether; tetrahydrofuran; cyclohexane / 2 h / Heating

2: 83 percent / HBr / acetic acid / 5 h / Heating

3: 83 percent / n-Bu₄N⁽¹⁺⁾*HSO₄^(1-), aq. NaOH / 1 h / Heating

4: 2.) NaOMe / 1) ethanol, reflux, 20 h; 2) DMF, 40 deg C, 1 h

With sodium hydroxide; hydrogen bromide; sodium methylate; tetra(n-butyl)ammonium hydrogensulfate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; diethyl ether; cyclohexane; acetic acid;
DOI:10.1021/jm00402a005