N-[4-(AMINOSULFONYL)-5-CHLORO-2-METHYLPHENYL]ACETAMIDE

Base Information

• Chemical Name: N-[4-(AMINOSULFONYL)-5-CHLORO-2-METHYLPHENYL]ACETAMIDE
• CAS No.: 17560-53-1
• Molecular Formula: C9H11 Cl N2 O3 S
• Molecular Weight: 262.717
• Hs Code.: 2935009090
• Mol file: 17560-53-1.mol

Synonyms:o-Acetotoluidide,5'-chloro-4'-sulfamoyl- (6CI,7CI,8CI); 5-Chloro-2-methyl-4-sulfamoylacetanilide

Chemical Property of N-[4-(AMINOSULFONYL)-5-CHLORO-2-METHYLPHENYL]ACETAMIDE

Chemical Property:

• Melting Point: >265 °C
• PKA: 9.55±0.60(Predicted)
• PSA: 97.64000
• Density: 1.462±0.06 g/cm3(Predicted)
• LogP: 3.10830

Purity/Quality:

99%min. ^*data from raw suppliers

N-[4-(Aminosulfonyl)-5-chloro-2-methylphenyl]acetamide 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-[4-(AMINOSULFONYL)-5-CHLORO-2-METHYLPHENYL]ACETAMIDE

There total 2 articles about N-[4-(AMINOSULFONYL)-5-CHLORO-2-METHYLPHENYL]ACETAMIDE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(5-chloro-2-methylphenyl)acetamide (5900-55-0) → 6-acetylamino-4-chloro-toluene-3-sulfonic acid amide (17560-53-1)

Guidance literature:

With chlorosulfonic acid; ammonium hydroxide;

DOI:10.1021/ja01529a062

Reference yield:

→ 6-acetylamino-4-chloro-toluene-3-sulfonic acid amide (17560-53-1)

Guidance literature:

5-Chlor-2-methylacetanilid, 1) Chlorsulfonsaeure / NaCl, 2) NH3 / H2O;

DOI:10.1021/jm00299a022

Reference yield:

6-acetylamino-4-chloro-toluene-3-sulfonic acid amide (17560-53-1) → 2-Amino-4-chloro-5-sulfamoylbenzamide (34121-17-0) + 4-chloro-5-sulfamoyl-2-ureido-benzoic acid (21501-33-7)

Guidance literature:

Multi-step reaction with 4 steps

1: potassium permanganate

2: hydrogenchloride

3: 1,4-dioxane

4: ammonium hydroxide

With 1,4-dioxane; hydrogenchloride; ammonium hydroxide; potassium permanganate;

upstream raw materials:

N-(5-chloro-2-methylphenyl)acetamide

Downstream raw materials:

2-acetylamino-4-chloro-5-sulfamoyl-benzoic acid

7-chloro-2,4-dioxo-1,4-dihydro-2H-benzo[d][1,3]oxazine-6-sulfonic acid amide

4-chloro-5-sulfamoylanthranilic acid

2-Amino-4-chloro-5-sulfamoylbenzamide

Refernces

• 1、 -. "Tetrahydro-halo-sulfamyl quinazolinones". . . Retrieved 2014/02/11.