dimethyl ((1R,1′R)-((2S,2′S)-(([1,1′-biphenyl]-4,4′-diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicarbamate

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Chemical Name:dimethyl ((1R,1′R)-((2S,2′S)-(([1,1′-biphenyl]-4,4′-diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicarbamate
CAS No.:1512624-44-0
Molecular Formula:C₄₂H₄₄N₆O₈
Molecular Weight:760.847
Hs Code.:

Synonyms:dimethyl ((1R,1′R)-((2S,2′S)-(([1,1′-biphenyl]-4,4′-diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicarbamate

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Chemical Property of dimethyl ((1R,1′R)-((2S,2′S)-(([1,1′-biphenyl]-4,4′-diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicarbamate

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Technology Process of dimethyl ((1R,1′R)-((2S,2′S)-(([1,1′-biphenyl]-4,4′-diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicarbamate

There total 6 articles about dimethyl ((1R,1′R)-((2S,2′S)-(([1,1′-biphenyl]-4,4′-diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicarbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 46.0%

: C₂₂H₂₆N₄O₂*2C₂HF₃O₂

: 50890-96-5
(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid

: 1512624-44-0
dimethyl ((1R,1′R)-((2S,2′S)-(([1,1′-biphenyl]-4,4′-diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicarbamate

Guidance literature:: With 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 1.25h;
DOI:10.1021/ml4003293

Reference yield: 29.0%

: 1013405-02-1
(2S,2′S)-N,N'-([1,1′-biphenyl]-4,4′-diyl)bis(pyrrolidine-2-carboxamide)

: 50890-96-5
(2R)-2-[(methoxycarbonyl)amino]-2-phenylacetic acid

: 1512624-44-0
dimethyl ((1R,1′R)-((2S,2′S)-(([1,1′-biphenyl]-4,4′-diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicarbamate

Guidance literature:: With O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1016/j.bioorg.2020.104089

Reference yield:

: 875-74-1
(R)-phenylglycine

: 1512624-44-0
dimethyl ((1R,1′R)-((2S,2′S)-(([1,1′-biphenyl]-4,4′-diylbis(azanediyl))bis(carbonyl))bis(pyrrolidine-2,1-diyl))bis(2-oxo-1-phenylethane-2,1-diyl))dicarbamate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium carbonate; sodium hydroxide / water / 3.25 h / 20 °C / Cooling with ice

2: 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine / dichloromethane / 1.25 h / 20 °C

With sodium carbonate; 1,2-dichloro-ethane; N-ethyl-N,N-diisopropylamine; sodium hydroxide; In dichloromethane; water;
DOI:10.1021/ml4003293