3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester

Base Information

Chemical Name:3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester
CAS No.:1346862-78-9
Molecular Formula:C₂₀H₁₇Br₂NO₅
Molecular Weight:511.167
Hs Code.:

Synonyms:3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester

Suppliers and Price of 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester

There total 5 articles about 3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1346863-07-7
4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester

: 1346862-78-9
3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester

Guidance literature:: With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; In chloroform; Reflux; Inert atmosphere;
DOI:10.1021/ml200217u

Reference yield:

: 93-40-3
(3,4-Dimethoxyphenyl)acetic acid

: 1346862-78-9
3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: trichlorophosphate / Heating; Inert atmosphere

1.2: Inert atmosphere

2.1: potassium tert-butylate / N,N-dimethyl-formamide / Heating; Inert atmosphere

3.1: alkali hydroxide / ethanol; water / 3 h / Inert atmosphere; Reflux

3.2: pH 2

4.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

4.2: 40 °C / Inert atmosphere

5.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / chloroform / Reflux; Inert atmosphere

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; potassium tert-butylate; 1,1'-carbonyldiimidazole; trichlorophosphate; In ethanol; chloroform; water; N,N-dimethyl-formamide; 1.1: Vilsmeier formylation / 1.2: Vilsmeier formylation;
DOI:10.1021/ml200217u

Reference yield:

: 127572-59-2
4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid ethyl ester

: 1346862-78-9
3,5-dibromo-4-(3,4-dimethoxyphenyl)-1H-pyrrole-2-carboxylic acid 4-methoxyphenyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: alkali hydroxide / ethanol; water / 3 h / Inert atmosphere; Reflux

1.2: pH 2

2.1: 1,1'-carbonyldiimidazole / N,N-dimethyl-formamide / 40 °C / Inert atmosphere

2.2: 40 °C / Inert atmosphere

3.1: 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione / chloroform / Reflux; Inert atmosphere

With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 1,1'-carbonyldiimidazole; In ethanol; chloroform; water; N,N-dimethyl-formamide;
DOI:10.1021/ml200217u