N₄-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid

Base Information

• Chemical Name: N₄-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid
• CAS No.: 1182206-89-8
• Molecular Formula: C₃₄H₃₃N₅O₉
• Molecular Weight: 655.664

Synonyms:N₄-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid

Chemical Property of N₄-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Useful:

Technology Process of N₄-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid

There total 1 articles about N₄-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

tert-butyl N4-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetate (1182206-79-6) → N4-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid (1182206-89-8)

Guidance literature:

With triethylsilane; trifluoroacetic acid; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/hlca.200900047

Reference yield:

N4-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid (1182206-89-8) + C27H29N7O7 + acetic anhydride (108-24-7) → ethyl {2-acetyl-1-[(2-amino-9-{2-[2-{[3-(2-amino-2-oxoethyl)-6-{[(benzyloxy)carbonyl]amino}-2-oxo-2,3-dihydropyrimidin-4-yl]methyl}-2-(2-ethoxy-2-oxoethyl)hydrazinyl]-2-oxoethyl}-6-oxo-6,9-dihydro-1H-purin-8-yl)methyl]hydrazinyl}acetate (1328885-94-4)

Guidance literature:

N₄-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dimethyl sulfoxide; Inert atmosphere; solid phase reaction;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; Inert atmosphere; solid phase reaction;

C₂₇H₂₉N₇O₇; acetic anhydride; Further stages;

DOI:10.1002/hlca.201100124

Reference yield:

N4-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid (1182206-89-8) + C27H29N7O7 + acetic anhydride (108-24-7) → ethyl {2-acetyl-1-[(2-amino-9-{2-[2-{[3-(2-{2-[(2-amino-9-{2-[2-{[3-(2-amino-2-oxoethyl)-6-{[(benzyloxy)carbonyl]amino}-2-oxo-2,3-dihydropyrimidin-4-yl]methyl}-2-(2-ethoxy-2-oxoethyl)hydrazinyl]-2-oxoethyl}-6-oxo-6,9-dihydro-1H-purin-8-yl)methyl]-2-(2-ethoxy-2-oxoethyl)hydrazinyl}-2-oxoethyl)-6-{[(benzyloxy)carbonyl]amino}-2-oxo-2,3-dihydropyrimidin-4-yl]methyl}-2-(2-ethoxy-2-oxoethyl)hydrazinyl]-2-oxoethyl}-6-oxo-6,9-dihydro-1H-purin-8-yl)methyl]hydrazinyl}acetate (1328885-95-5)

Guidance literature:

N₄-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetic acid; With N-ethyl-N,N-diisopropylamine; HATU; In dimethyl sulfoxide; Inert atmosphere; solid phase reaction;

With 1,8-diazabicyclo[5.4.0]undec-7-ene; In dimethyl sulfoxide; Inert atmosphere; solid phase reaction;

C₂₇H₂₉N₇O₇; acetic anhydride; Further stages;

DOI:10.1002/hlca.201100124

upstream raw materials:

tert-butyl N₄-[(benzyloxy)carbonyl]-6-[(1-(2-ethoxy-2-oxoethyl)-2-{[(9H-fluoren-9-yl)methoxy]carbonyl}hydrazino)methyl]cytosine-1-acetate

Downstream raw materials:

ethyl {2-acetyl-1-[(2-amino-9-{2-[2-{[3-(2-amino-2-oxoethyl)-6-{[(benzyloxy)carbonyl]amino}-2-oxo-2,3-dihydropyrimidin-4-yl]methyl}-2-(2-ethoxy-2-oxoethyl)hydrazinyl]-2-oxoethyl}-6-oxo-6,9-dihydro-1H-purin-8-yl)methyl]hydrazinyl}acetate

ethyl {2-acetyl-1-[(2-amino-9-{2-[2-{[3-(2-{2-[(2-amino-9-{2-[2-{[3-(2-amino-2-oxoethyl)-6-{[(benzyloxy)carbonyl]amino}-2-oxo-2,3-dihydropyrimidin-4-yl]methyl}-2-(2-ethoxy-2-oxoethyl)hydrazinyl]-2-oxoethyl}-6-oxo-6,9-dihydro-1H-purin-8-yl)methyl]-2-(2-ethoxy-2-oxoethyl)hydrazinyl}-2-oxoethyl)-6-{[(benzyloxy)carbonyl]amino}-2-oxo-2,3-dihydropyrimidin-4-yl]methyl}-2-(2-ethoxy-2-oxoethyl)hydrazinyl]-2-oxoethyl}-6-oxo-6,9-dihydro-1H-purin-8-yl)methyl]hydrazinyl}acetate

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