2,4-dimethoxy-3-methyl-6-(2-oxopropyl)benzoic acid

Base Information

• Chemical Name: 2,4-dimethoxy-3-methyl-6-(2-oxopropyl)benzoic acid
• CAS No.: 102712-99-2
• Molecular Formula: C₁₃H₁₆O₅
• Molecular Weight: 252.267
• Mol file: 102712-99-2.mol

Synonyms:2,4-dimethoxy-3-methyl-6-(2-oxopropyl)benzoic acid

Chemical Property of 2,4-dimethoxy-3-methyl-6-(2-oxopropyl)benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,4-dimethoxy-3-methyl-6-(2-oxopropyl)benzoic acid

There total 6 articles about 2,4-dimethoxy-3-methyl-6-(2-oxopropyl)benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethyl orselinate (2524-37-0) → 2,4-dimethoxy-3-methyl-6-(2-oxopropyl)benzoic acid (102712-99-2)

Guidance literature:

Multi-step reaction with 6 steps

1: 23 percent / Br₂ / acetic acid / 15 h / Ambient temperature

2: 91 percent / potassium carbonate / acetone / 19 h / Heating

3: 74 percent / 1.9M butyl-lithium / tetrahydrofuran; hexane / 1.) -78 deg C, a few min; 2.) up to RT

4: 86 percent / 20percent aq. potassium hydroxide / dimethylsulfoxide / 5 h / Heating

5: 1.) 1.6M butyl-lithium, diisopropylamine; 2.) H₂O / 1.) THF, hexane, a.) -78 deg C up to RT, b.) RT, 3 h; 2.) THF, hexane,

6: 2.) aq. sodium hydroxide / 1.) pyridine, ether, 3 h; 2.) 30 min

With potassium hydroxide; sodium hydroxide; n-butyllithium; water; bromine; potassium carbonate; diisopropylamine; In tetrahydrofuran; hexane; acetic acid; dimethyl sulfoxide; acetone;

Reference yield:

ethyl 2,4-dimethoxy-3,6-dimethylbenzoate (38629-38-8) → 2,4-dimethoxy-3-methyl-6-(2-oxopropyl)benzoic acid (102712-99-2)

Guidance literature:

Multi-step reaction with 3 steps

1: 86 percent / 20percent aq. potassium hydroxide / dimethylsulfoxide / 5 h / Heating

2: 1.) 1.6M butyl-lithium, diisopropylamine; 2.) H₂O / 1.) THF, hexane, a.) -78 deg C up to RT, b.) RT, 3 h; 2.) THF, hexane,

3: 2.) aq. sodium hydroxide / 1.) pyridine, ether, 3 h; 2.) 30 min

With potassium hydroxide; sodium hydroxide; n-butyllithium; water; diisopropylamine; In dimethyl sulfoxide;

Reference yield:

ethyl 3-bromo-2,4-dihydroxy-6-methylbenzoate (152676-32-9) → 2,4-dimethoxy-3-methyl-6-(2-oxopropyl)benzoic acid (102712-99-2)

Guidance literature:

Multi-step reaction with 5 steps

1: 91 percent / potassium carbonate / acetone / 19 h / Heating

2: 74 percent / 1.9M butyl-lithium / tetrahydrofuran; hexane / 1.) -78 deg C, a few min; 2.) up to RT

3: 86 percent / 20percent aq. potassium hydroxide / dimethylsulfoxide / 5 h / Heating

4: 1.) 1.6M butyl-lithium, diisopropylamine; 2.) H₂O / 1.) THF, hexane, a.) -78 deg C up to RT, b.) RT, 3 h; 2.) THF, hexane,

5: 2.) aq. sodium hydroxide / 1.) pyridine, ether, 3 h; 2.) 30 min

With potassium hydroxide; sodium hydroxide; n-butyllithium; water; potassium carbonate; diisopropylamine; In tetrahydrofuran; hexane; dimethyl sulfoxide; acetone;

upstream raw materials:

acetic anhydride

2,4-O-dimethyl-β-orcinolcarboxylic acid

ethyl 2,4-dimethoxy-3,6-dimethylbenzoate

ethyl orselinate