Technology Process of (1S,2R,5R)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexylcarbamic acid tert-butyl ester
There total 9 articles about (1S,2R,5R)-2-({2-[(5-chloropyridin-2-yl)amino]-2-oxoacetyl}amino)-5-[(dimethylamino)carbonyl]cyclohexylcarbamic acid tert-butyl ester which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
triethylamine;
In
ethanol;
at 80 ℃;
for 10h;
- Guidance literature:
-
Multi-step reaction with 8 steps
1.1: potassium iodide; iodine / dichloromethane; water / 4 h / 5 - 25 °C / Alkaline conditions
2.1: sodium hydroxide / water / 4 h / 25 - 30 °C
3.1: ammonium hydroxide / ethanol / 24 h / 40 - 45 °C
3.2: 2 h / 20 - 25 °C
4.1: triethylamine / dichloromethane / 2 h / 0 - 25 °C
5.1: sodium azide / N,N-dimethyl-formamide / 24 h / 65 - 75 °C
6.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 25 - 30 °C
6.2: 24 h / 35 - 45 °C
7.1: palladium on activated charcoal; ammonium formate / ethanol / 4 h
7.2: 3 h / 25 - 30 °C
8.1: triethylamine / ethanol / 10 h / 80 °C
With
ammonium hydroxide; sodium azide; lithium hydroxide monohydrate; palladium on activated charcoal; iodine; ammonium formate; triethylamine; potassium iodide; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: acetone / 2 h / 40 °C
1.2: 2 h
2.1: potassium iodide; iodine / dichloromethane; water / 4 h / 5 - 25 °C / Alkaline conditions
3.1: sodium hydroxide / water / 4 h / 25 - 30 °C
4.1: ammonium hydroxide / ethanol / 24 h / 40 - 45 °C
4.2: 2 h / 20 - 25 °C
5.1: triethylamine / dichloromethane / 2 h / 0 - 25 °C
6.1: sodium azide / N,N-dimethyl-formamide / 24 h / 65 - 75 °C
7.1: lithium hydroxide monohydrate / water; tetrahydrofuran / 24 h / 25 - 30 °C
7.2: 24 h / 35 - 45 °C
8.1: palladium on activated charcoal; ammonium formate / ethanol / 4 h
8.2: 3 h / 25 - 30 °C
9.1: triethylamine / ethanol / 10 h / 80 °C
With
ammonium hydroxide; sodium azide; lithium hydroxide monohydrate; palladium on activated charcoal; iodine; ammonium formate; triethylamine; potassium iodide; sodium hydroxide;
In
tetrahydrofuran; ethanol; dichloromethane; water; N,N-dimethyl-formamide; acetone;
