(E)-ethyl 3-(phenylamino)-3-(4-(4-(trifluoromethoxy)benzyl)phenyl)acrylate

Base Information

Chemical Name:(E)-ethyl 3-(phenylamino)-3-(4-(4-(trifluoromethoxy)benzyl)phenyl)acrylate
CAS No.:1361006-03-2
Molecular Formula:C₂₅H₂₂F₃NO₃
Molecular Weight:441.45
Hs Code.:

Synonyms:(E)-ethyl 3-(phenylamino)-3-(4-(4-(trifluoromethoxy)benzyl)phenyl)acrylate

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Chemical Property of (E)-ethyl 3-(phenylamino)-3-(4-(4-(trifluoromethoxy)benzyl)phenyl)acrylate

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Technology Process of (E)-ethyl 3-(phenylamino)-3-(4-(4-(trifluoromethoxy)benzyl)phenyl)acrylate

There total 4 articles about (E)-ethyl 3-(phenylamino)-3-(4-(4-(trifluoromethoxy)benzyl)phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1361005-34-6
ethyl 3-oxo-3-(4-(4-(trifluoromethoxy)benzyl)phenyl)propanoate

: 62-53-3
aniline

: 1361006-03-2
(E)-ethyl 3-(phenylamino)-3-(4-(4-(trifluoromethoxy)benzyl)phenyl)acrylate

Guidance literature:: With acetic acid; In ethanol; Inert atmosphere; Reflux;
DOI:10.1021/jm201179h

Reference yield:

: 1361005-59-5
4-(4-(trifluoromethoxy)benzyl)benzaldehyde

: 1361006-03-2
(E)-ethyl 3-(phenylamino)-3-(4-(4-(trifluoromethoxy)benzyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: niobium pentachloride / dichloromethane / 48 h / 20 °C / Inert atmosphere

2: acetic acid / ethanol / Inert atmosphere; Reflux

With niobium pentachloride; acetic acid; In ethanol; dichloromethane;
DOI:10.1021/jm201179h

Reference yield:

: 50824-05-0
4-trifluoromethoxybenzyl bromide

: 1361006-03-2
(E)-ethyl 3-(phenylamino)-3-(4-(4-(trifluoromethoxy)benzyl)phenyl)acrylate

Guidance literature:: Multi-step reaction with 3 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate / tetrahydrofuran; water / 5 h / 80 °C / Inert atmosphere

2: niobium pentachloride / dichloromethane / 48 h / 20 °C / Inert atmosphere

3: acetic acid / ethanol / Inert atmosphere; Reflux

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; niobium pentachloride; potassium carbonate; acetic acid; In tetrahydrofuran; ethanol; dichloromethane; water;
DOI:10.1021/jm201179h