<1-(1,1-dimethylethoxycarbonyl)-5-methyl-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate

Base Information

Chemical Name:<1-(1,1-dimethylethoxycarbonyl)-5-methyl-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate
CAS No.:175689-42-6
Molecular Formula:C₂₁H₂₃N₃O₄
Molecular Weight:381.431
Hs Code.:

Synonyms:<1-(1,1-dimethylethoxycarbonyl)-5-methyl-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate

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Chemical Property of <1-(1,1-dimethylethoxycarbonyl)-5-methyl-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate

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Technology Process of <1-(1,1-dimethylethoxycarbonyl)-5-methyl-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate

There total 5 articles about <1-(1,1-dimethylethoxycarbonyl)-5-methyl-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 29.0%

: 175689-40-4
<1-(1,1-dimethylethoxycarbonyl)-5-methyl-2-pyrrolyl>methyl 4-phenyl-3(E)-butenoate

: 175689-42-6
<1-(1,1-dimethylethoxycarbonyl)-5-methyl-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate

Guidance literature:: With 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 0 ℃; overnight;
DOI:10.1021/jo952127q

Reference yield:

: 1192-79-6
formyl-2 methyl-5 pyrrole

: 175689-42-6
<1-(1,1-dimethylethoxycarbonyl)-5-methyl-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 24 h / 25 °C

2: 97 percent / NaBH₄ / methanol / 1 h / 0 °C

3: 52 percent / CH₂Cl₂ / Ambient temperature; overnight

4: 29 percent / p-acetamidobenzenesulfonyl azide, DBU / acetonitrile / 0 °C / overnight

With sodium tetrahydroborate; 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo952127q

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 175689-42-6
<1-(1,1-dimethylethoxycarbonyl)-5-methyl-2-pyrrolyl>methyl 2-diazo-4-phenyl-3(E)-butenoate

Guidance literature:: Multi-step reaction with 4 steps

1: acetonitrile / 24 h / 25 °C

2: 97 percent / NaBH₄ / methanol / 1 h / 0 °C

3: 52 percent / CH₂Cl₂ / Ambient temperature; overnight

4: 29 percent / p-acetamidobenzenesulfonyl azide, DBU / acetonitrile / 0 °C / overnight

With sodium tetrahydroborate; 4-acetamidobenzenesulfonyl azide; 1,8-diazabicyclo[5.4.0]undec-7-ene; In methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo952127q