2-Benzyl-3,3,3-trifluoro-2-[(S)-2-(2-nitro-benzenesulfonylamino)-3-phenyl-propionylamino]-propionic acid ethyl ester

Base Information

• Chemical Name: 2-Benzyl-3,3,3-trifluoro-2-[(S)-2-(2-nitro-benzenesulfonylamino)-3-phenyl-propionylamino]-propionic acid ethyl ester
• CAS No.: 467221-70-1
• Molecular Formula: C₂₇H₂₆F₃N₃O₇S
• Molecular Weight: 593.581

Synonyms:2-Benzyl-3,3,3-trifluoro-2-[(S)-2-(2-nitro-benzenesulfonylamino)-3-phenyl-propionylamino]-propionic acid ethyl ester

Chemical Property of 2-Benzyl-3,3,3-trifluoro-2-[(S)-2-(2-nitro-benzenesulfonylamino)-3-phenyl-propionylamino]-propionic acid ethyl ester

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Technology Process of 2-Benzyl-3,3,3-trifluoro-2-[(S)-2-(2-nitro-benzenesulfonylamino)-3-phenyl-propionylamino]-propionic acid ethyl ester

There total 2 articles about 2-Benzyl-3,3,3-trifluoro-2-[(S)-2-(2-nitro-benzenesulfonylamino)-3-phenyl-propionylamino]-propionic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

H-(R,S)-(α-trifluoromethyl)Phe-OEt + o-nitrobenzenesulfonyl-Phe-Br → 2-Benzyl-3,3,3-trifluoro-2-[(S)-2-(2-nitro-benzenesulfonylamino)-3-phenyl-propionylamino]-propionic acid ethyl ester (467221-70-1)

Guidance literature:

With 2,3,5-trimethyl-pyridine; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jo020280w

Reference yield:

(S)-2-(2-nitrophenylsulfonamido)-3-phenylpropanoic acid (53793-18-3) → 2-Benzyl-3,3,3-trifluoro-2-[(S)-2-(2-nitro-benzenesulfonylamino)-3-phenyl-propionylamino]-propionic acid ethyl ester (467221-70-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1-bromo-N,N,2-trimethyl-1-propenylamine / CH₂Cl₂ / 0.25 h

2: 92 percent / collidine / CH₂Cl₂ / 3 h / 20 °C

With 2,3,5-trimethyl-pyridine; 1-bromo-N,N,2-trimethyl-1-propen-1-amine; In dichloromethane;

DOI:10.1021/jo020280w

Reference yield: 80.0%

2-Benzyl-3,3,3-trifluoro-2-[(S)-2-(2-nitro-benzenesulfonylamino)-3-phenyl-propionylamino]-propionic acid ethyl ester (467221-70-1) → H-Phe-(R,S)-(α-trifluoromethyl)Phe-OEt

Guidance literature:

With potassium carbonate; thiophenol; In N,N-dimethyl-formamide; for 0.166667h;

DOI:10.1021/jo020280w

upstream raw materials:

(S)-2-(2-nitrophenylsulfonamido)-3-phenylpropanoic acid

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