9-(tert-butoxycarbonyl)-3-ethyl-2,8-dimethyldipyrromethane-1-carboxylate

Base Information

• Chemical Name: 9-(tert-butoxycarbonyl)-3-ethyl-2,8-dimethyldipyrromethane-1-carboxylate
• CAS No.: 443755-00-8
• Molecular Formula: C₂₆H₃₂N₂O₄
• Molecular Weight: 436.551
• Mol file: 443755-00-8.mol

Synonyms:9-(tert-butoxycarbonyl)-3-ethyl-2,8-dimethyldipyrromethane-1-carboxylate

Chemical Property of 9-(tert-butoxycarbonyl)-3-ethyl-2,8-dimethyldipyrromethane-1-carboxylate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 9-(tert-butoxycarbonyl)-3-ethyl-2,8-dimethyldipyrromethane-1-carboxylate

There total 1 articles about 9-(tert-butoxycarbonyl)-3-ethyl-2,8-dimethyldipyrromethane-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

benzyl 5-(acetoxymethyl)-4-ethyl-3-methyl-1H-pyrrole-2-carboxylate (3750-36-5) + tert-butyl 3-methylpyrrole-2-carboxylate (3284-48-8) → 9-(tert-butoxycarbonyl)-3-ethyl-2,8-dimethyldipyrromethane-1-carboxylate (443755-00-8)

Guidance literature:

With acetic acid; In 1,2-dichloro-ethane; at 36 ℃; Heating;

DOI:10.1021/jo020105f

Reference yield:

benzyl 5-(acetoxymethyl)-4-ethyl-3-methyl-1H-pyrrole-2-carboxylate (3750-36-5) + 9-(tert-butoxycarbonyl)-3-ethyl-2,8-dimethyldipyrromethane-1-carboxylate (443755-00-8) → 2,5-bis(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolylmethyl)-3-methylpyrrole (443755-01-9)

Guidance literature:

9-(tert-butoxycarbonyl)-3-ethyl-2,8-dimethyldipyrromethane-1-carboxylate; With trifluoroacetic acid; at 20 ℃; for 0.333333h;

benzyl 5-(acetoxymethyl)-4-ethyl-3-methyl-1H-pyrrole-2-carboxylate; In dichloromethane; 1,2-dichloro-ethane; for 2h; Further stages.; Heating;

DOI:10.1021/jo020105f

Reference yield:

9-(tert-butoxycarbonyl)-3-ethyl-2,8-dimethyldipyrromethane-1-carboxylate (443755-00-8) → dibenzyl 8-trichloroacetyl-3,12-diethyl-2,7,13-trimethyltripyrrane-1,14-dicarboxylate (443755-02-0)

Guidance literature:

Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / 0.33 h / 20 °C

1.2: 0.2089 g / CH₂Cl₂; 1,2-dichloro-ethane / 2 h / Heating

2.1: 87 percent / (dimethylamino)pyridine / CH₂Cl₂ / 0.5 h

With dmap; trifluoroacetic acid; In dichloromethane;

DOI:10.1021/jo020105f

upstream raw materials:

benzyl 5-(acetoxymethyl)-4-ethyl-3-methyl-1H-pyrrole-2-carboxylate

tert-butyl 3-methylpyrrole-2-carboxylate

Downstream raw materials:

2,5-bis(5-benzyloxycarbonyl-3-ethyl-4-methyl-2-pyrrolylmethyl)-3-methylpyrrole

dibenzyl 8-trichloroacetyl-3,12-diethyl-2,7,13-trimethyltripyrrane-1,14-dicarboxylate