methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate

Base Information

Chemical Name:methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate
CAS No.:1024036-96-1
Molecular Formula:C₂₃H₃₅N₃O₃S
Molecular Weight:433.615
Hs Code.:

Synonyms:methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate

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Chemical Property of methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate

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Technology Process of methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate

There total 3 articles about methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 865157-03-5,247259-31-0,957471-98-6
methyl-(R)-3-piperidine acetate hydrochloride

: 1024036-99-4
6-chloro-N-cyclohexyl-2-propylsulfanylpyridine-3-carboxamide

: 1024036-96-1
methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate

Guidance literature:: With potassium carbonate; In propyl cyanide; at 170 ℃; for 2h; Product distribution / selectivity; Microwave irradiation;

Reference yield:

: 1003872-51-2
2,6-dichloro-N-cyclohexyl-pyridine-3-carboxamide

: 1024036-96-1
methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 25 °C

1.2: 2 h / 25 °C

2.1: potassium carbonate / propyl cyanide / 2 h / 170 °C / Microwave irradiation

With sodium hexamethyldisilazane; potassium carbonate; In tetrahydrofuran; propyl cyanide; N,N-dimethyl-formamide;
DOI:10.1021/jm300592r

Reference yield:

: 58584-83-1
2,6-dichloronicotinoyl chloride

: 1024036-96-1
methyl 2-[(3R)-1-[5-(cyclohexylcarbamoyl)-6-propylsulfanyl-pyridin-2-yl]-3-piperidyl]acetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 15 °C

2.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.17 h / 25 °C

2.2: 2 h / 25 °C

3.1: potassium carbonate / propyl cyanide / 2 h / 170 °C / Microwave irradiation

With sodium hexamethyldisilazane; potassium carbonate; In tetrahydrofuran; propyl cyanide; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm300592r