(2R,4R)-6-Benzenesulfonylmethyl-2-isopropoxy-4-phenyl-3,4-dihydro-2H-pyran

Base Information

• Chemical Name: (2R,4R)-6-Benzenesulfonylmethyl-2-isopropoxy-4-phenyl-3,4-dihydro-2H-pyran
• CAS No.: 161420-36-6
• Molecular Formula: C₂₁H₂₄O₄S
• Molecular Weight: 372.485
• Mol file: 161420-36-6.mol

Synonyms:(2R,4R)-6-Benzenesulfonylmethyl-2-isopropoxy-4-phenyl-3,4-dihydro-2H-pyran

Chemical Property of (2R,4R)-6-Benzenesulfonylmethyl-2-isopropoxy-4-phenyl-3,4-dihydro-2H-pyran

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,4R)-6-Benzenesulfonylmethyl-2-isopropoxy-4-phenyl-3,4-dihydro-2H-pyran

There total 1 articles about (2R,4R)-6-Benzenesulfonylmethyl-2-isopropoxy-4-phenyl-3,4-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

vinyl isopropyl ether (926-65-8) + (E)-4-phenyl-1-phenylsulfonyl-3-buten-2-one (32117-28-5) → (2R,4R)-6-Benzenesulfonylmethyl-2-isopropoxy-4-phenyl-3,4-dihydro-2H-pyran (161420-36-6)

Guidance literature:

With diisopropoxytitanium(IV) dibromide; 4 A molecular sieve; (R,R)-TADDOL; In dichloromethane; at -70 ℃; for 20h;

DOI:10.1246/cl.1994.1637

Reference yield: 95.0%

(2R,4R)-6-Benzenesulfonylmethyl-2-isopropoxy-4-phenyl-3,4-dihydro-2H-pyran (161420-36-6) → (R)-2-Benzenesulfonyl-5-phenyl-cyclohex-2-enone (161420-39-9)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; for 2h; Ambient temperature;

DOI:10.1246/cl.1994.1637

Reference yield:

(2R,4R)-6-Benzenesulfonylmethyl-2-isopropoxy-4-phenyl-3,4-dihydro-2H-pyran (161420-36-6) → (R)-3-phenylcyclohexanone (20795-53-3,57344-86-2,113829-97-3,34993-51-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 95 percent / HCl / tetrahydrofuran / 2 h / Ambient temperature

2: H₂, 10percent Pd-C / tetrahydrofuran; ethanol

3: n-Bu₃SnH, AIBN / benzene / 4 h / Heating

With hydrogenchloride; palladium on activated charcoal; 2,2'-azobis(isobutyronitrile); hydrogen; tri-n-butyl-tin hydride; In tetrahydrofuran; ethanol; benzene;

DOI:10.1246/cl.1994.1637

upstream raw materials:

vinyl isopropyl ether

(E)-4-phenyl-1-phenylsulfonyl-3-buten-2-one

Downstream raw materials:

(R)-2-Benzenesulfonyl-5-phenyl-cyclohex-2-enone

(R)-3-phenylcyclohexanone