N-[6-(7-Chloro-8-hydroxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexyl]-formamide

Base Information

Chemical Name:N-[6-(7-Chloro-8-hydroxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexyl]-formamide
CAS No.:171285-58-8
Molecular Formula:C₂₃H₂₉ClN₂O₂
Molecular Weight:400.948
Hs Code.:

Synonyms:N-[6-(7-Chloro-8-hydroxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexyl]-formamide

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Chemical Property of N-[6-(7-Chloro-8-hydroxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexyl]-formamide

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Technology Process of N-[6-(7-Chloro-8-hydroxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexyl]-formamide

There total 10 articles about N-[6-(7-Chloro-8-hydroxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexyl]-formamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 171285-65-7
N-[6-(7-Chloro-8-methoxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexyl]-formamide

: 171285-58-8
N-[6-(7-Chloro-8-hydroxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexyl]-formamide

Guidance literature:: With boron tribromide; In dichloromethane; chloroform; for 1h; Yield given; Ambient temperature;
DOI:10.1021/jm00021a018

Reference yield:

: 7569-87-1
3-chloro-4-methoxyphenethylamine

: 171285-58-8
N-[6-(7-Chloro-8-hydroxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexyl]-formamide

Guidance literature:: Multi-step reaction with 7 steps

1: 50 percent / tetrahydrofuran / 18 h / Heating

2: 95 percent / 99percent CF₃COOH, 99percent CH₃SO₃H / 18 h / Heating

3: 1.) 1-hydroxybenzotriazole hydrate, dicylohexylcarbodiimide, 2.) Et₃N / 1.) DMF, 3 h, 2.) DMF, RT, 48 h

4: 79 percent / ISi(Me)3 / acetonitrile / 0.5 h / Ambient temperature

5: 85 percent / LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 2 h / Ambient temperature

6: 80 percent / ethyl formate / 18 h / Ambient temperature

7: 1 M BBr₃ / CHCl₃; CH₂Cl₂ / 1 h / Ambient temperature

With lithium aluminium tetrahydride; methanesulfonic acid; trimethylsilyl iodide; sulfuric acid; boron tribromide; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; trifluoroacetic acid; formic acid ethyl ester; In tetrahydrofuran; dichloromethane; chloroform; acetonitrile;
DOI:10.1021/jm00021a018

Reference yield:

: 1947-00-8
6-(benzyloxycarbonylamino)hexanoic acid

: 171285-58-8
N-[6-(7-Chloro-8-hydroxy-1-phenyl-1,2,4,5-tetrahydro-benzo[d]azepin-3-yl)-hexyl]-formamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) 1-hydroxybenzotriazole hydrate, dicylohexylcarbodiimide, 2.) Et₃N / 1.) DMF, 3 h, 2.) DMF, RT, 48 h

2: 79 percent / ISi(Me)3 / acetonitrile / 0.5 h / Ambient temperature

3: 85 percent / LiAlH₄, 98percent H₂SO₄ / tetrahydrofuran / 2 h / Ambient temperature

4: 80 percent / ethyl formate / 18 h / Ambient temperature

5: 1 M BBr₃ / CHCl₃; CH₂Cl₂ / 1 h / Ambient temperature

With lithium aluminium tetrahydride; trimethylsilyl iodide; sulfuric acid; boron tribromide; 1-hydroxybenzotriazol-hydrate; triethylamine; dicyclohexyl-carbodiimide; formic acid ethyl ester; In tetrahydrofuran; dichloromethane; chloroform; acetonitrile;
DOI:10.1021/jm00021a018