7-METHYL-DL-TRYPTOPHAN

Base Information

• Chemical Name: 7-METHYL-DL-TRYPTOPHAN
• CAS No.: 17332-70-6
• Molecular Formula: C₁₂H₁₄N₂O₂
• Molecular Weight: 218.255
• Hs Code.: 2933998090
• Mol file: 17332-70-6.mol

Synonyms:DL-Tryptophan,7-methyl-; Tryptophan, 7-methyl-, DL- (8CI); (?à)-7-Methyltryptophan; 7-Methyl-DL-tryptophan;7-Methyltryptophan; DL-7-Methyltryptophan; NSC 9365

Chemical Property of 7-METHYL-DL-TRYPTOPHAN

Chemical Property:

• Melting Point: 296 °C (decomp)
• Refractive Index: 1.677
• Boiling Point: 448.8±45.0 °C(Predicted)
• PKA: 2.26±0.10(Predicted)
• PSA: 79.11000
• Density: 1.313±0.06 g/cm3(Predicted)
• LogP: 2.13100
• Storage Temp.: 2-8°C

Purity/Quality:

98%Min ^*data from raw suppliers

7-Methyl-DL-tryptophan ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 7-METHYL-DL-TRYPTOPHAN

There total 4 articles about 7-METHYL-DL-TRYPTOPHAN which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.4%

7-methyl-N-acetyltryptophan → 7-methyl-DL-tryptophan (3456-73-3,17332-70-6,33468-36-9,99295-80-4)

Guidance literature:

With hydrogenchloride; In water; at 100 ℃; for 3h; Temperature;

Reference yield:

4-(7-methyl-1'H-indole-3'-ylmethylene)-2-methyl-5(4H)-oxazolone → 7-methyl-DL-tryptophan (3456-73-3,17332-70-6,33468-36-9,99295-80-4)

Guidance literature:

Multi-step reaction with 3 steps

1: acetonitrile; water / 3 h / 80 °C

2: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 25 °C

3: hydrogenchloride / water / 3 h / 100 °C

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; In methanol; water; acetonitrile;

Reference yield:

7-methyl-1H-indole-3-carbaldehyde (4771-50-0) → 7-methyl-DL-tryptophan (3456-73-3,17332-70-6,33468-36-9,99295-80-4)

Guidance literature:

Multi-step reaction with 4 steps

1: acetic anhydride; sodium acetate / 3 h / 100 °C / Inert atmosphere

2: acetonitrile; water / 3 h / 80 °C

3: 5%-palladium/activated carbon; hydrogen / methanol / 3 h / 25 °C

4: hydrogenchloride / water / 3 h / 100 °C

With hydrogenchloride; 5%-palladium/activated carbon; hydrogen; sodium acetate; acetic anhydride; In methanol; water; acetonitrile;

upstream raw materials:

7-methyl-1H-indole-3-carbaldehyde

Refernces