1-{4'-[3-Methyl-4-(3-phenyl-butylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Base Information

Chemical Name:1-{4'-[3-Methyl-4-(3-phenyl-butylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid
CAS No.:1280205-97-1
Molecular Formula:C₃₀H₃₀N₂O₃
Molecular Weight:466.58
Hs Code.:

Synonyms:1-{4'-[3-Methyl-4-(3-phenyl-butylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

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Chemical Property of 1-{4'-[3-Methyl-4-(3-phenyl-butylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

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Technology Process of 1-{4'-[3-Methyl-4-(3-phenyl-butylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

There total 7 articles about 1-{4'-[3-Methyl-4-(3-phenyl-butylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 16251-77-7
3-Phenylbutyraldehyde

: 1280205-94-8
ethyl 1-(4'-(4-amino-3-methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate

: 1280205-97-1
1-{4'-[3-Methyl-4-(3-phenyl-butylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Guidance literature:: 3-Phenylbutyraldehyde; ethyl 1-(4'-(4-amino-3-methylisoxazol-5-yl)-[1,1'-biphenyl]-4-yl)cyclopropanecarboxylate; With sodium tris(acetoxy)borohydride; In dichloromethane;

With lithium hydroxide monohydrate; water; In methanol; dichloromethane; at 60 ℃; for 1h;

With water;

Reference yield:

: 1257213-52-7
1-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]cyclopropane-1-carboxylic acid ethyl ester

: 1280205-97-1
1-{4'-[3-Methyl-4-(3-phenyl-butylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethyl acetate; 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 1 h

3.1: sodium tris(acetoxy)borohydride / dichloromethane

3.2: 1 h / 60 °C

With sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; trifluoroacetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate;

Reference yield:

: 16532-79-9
4-Bromophenylacetonitrile

: 1280205-97-1
1-{4'-[3-Methyl-4-(3-phenyl-butylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid

Guidance literature:: Multi-step reaction with 7 steps

1.1: potassium hydroxide; tetrabutylammomium bromide / toluene; water / 2 h / 20 °C

2.1: potassium hydroxide; ethylene glycol / 4 h / 180 °C

2.2: Acidic conditions

3.1: sulfuric acid / 1 h / 75 °C

4.1: potassium acetate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / 1,4-dioxane / 2 h / 80 °C / Inert atmosphere

5.1: sodium hydrogencarbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / ethyl acetate; 1,2-dimethoxyethane; water / 80 °C / Inert atmosphere

6.1: trifluoroacetic acid / dichloromethane / 1 h

7.1: sodium tris(acetoxy)borohydride / dichloromethane

7.2: 1 h / 60 °C

With sulfuric acid; tetrabutylammomium bromide; potassium acetate; sodium tris(acetoxy)borohydride; sodium hydrogencarbonate; ethylene glycol; trifluoroacetic acid; potassium hydroxide; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,4-dioxane; 1,2-dimethoxyethane; dichloromethane; water; ethyl acetate; toluene;