2-[2-(2-{[2-(2-amino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid

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Chemical Name:2-[2-(2-{[2-(2-amino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid
CAS No.:934715-82-9
Molecular Formula:C₃₆H₅₉N₅O₆
Molecular Weight:657.894
Hs Code.:

2-[2-(2-{[2-(2-amino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid

Synonyms:2-[2-(2-{[2-(2-amino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid

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Chemical Property of 2-[2-(2-{[2-(2-amino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid

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Technology Process of 2-[2-(2-{[2-(2-amino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid

There total 10 articles about 2-[2-(2-{[2-(2-amino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13139-15-6,53296-34-7
N-tert-butoxycarbonyl-L-leucine

: 934715-82-9
2-[2-(2-{[2-(2-amino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: 92 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄ / CH₂Cl₂ / 20 °C

2: 94 percent / lithium hydroxide / methanol

3: 83 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄; 3-(diethoxyphosphoryloxy)-3H-benzo[d][1,2,3]triazin-4-one / acetonitrile / 20 °C

4: HCl; anisole / tetrahydrofuran

With hydrogenchloride; lithium hydroxide; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;
DOI:10.1021/jo061830j

Reference yield:

: 934715-56-7
2-[2-(2-{[2-(2-tert-butoxycarbonylamino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid methyl ester

: 934715-82-9
2-[2-(2-{[2-(2-amino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid

Guidance literature:: With hydrogenchloride; methoxybenzene; In tetrahydrofuran;
DOI:10.1021/jo061830j

Reference yield:

: 934715-54-5
(S)-2-[(S)-4-Methyl-2-((R)-3-methyl-2-methylamino-butyrylamino)-pentanoylamino]-3-phenyl-propionic acid methyl ester

: 934715-82-9
2-[2-(2-{[2-(2-amino-4-methyl-pentanoylamino)-3-cyclohexyl-propionyl]-methyl-amino}-3-methyl-butyrylamino)-4-methyl-pentanoylamino]-3-phenyl-propionic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / ethyldiisopropylamine; 2-(1H-benzotriazol-1-yl)-1,1,3,3-tetramethyluronium BF₄; 3-(diethoxyphosphoryloxy)-3H-benzo[d][1,2,3]triazin-4-one / acetonitrile / 20 °C

2: HCl; anisole / tetrahydrofuran

With hydrogenchloride; O-(benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium tetrafluoroborate; methoxybenzene; N-ethyl-N,N-diisopropylamine; 3-[(diethoxyphosphinyl)oxy]-1,2,3-benzotriazin-4(3H)-one; In tetrahydrofuran; acetonitrile;
DOI:10.1021/jo061830j