(1S,2R,4S,5S)-1-Carbamoyl-5-hydroxy-4-iodo-2-phenyl-cyclohexanecarboxylic acid methyl ester

Base Information

Chemical Name:(1S,2R,4S,5S)-1-Carbamoyl-5-hydroxy-4-iodo-2-phenyl-cyclohexanecarboxylic acid methyl ester
CAS No.:190074-05-6
Molecular Formula:C₁₅H₁₈INO₄
Molecular Weight:403.217
Hs Code.:

Synonyms:(1S,2R,4S,5S)-1-Carbamoyl-5-hydroxy-4-iodo-2-phenyl-cyclohexanecarboxylic acid methyl ester

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Chemical Property of (1S,2R,4S,5S)-1-Carbamoyl-5-hydroxy-4-iodo-2-phenyl-cyclohexanecarboxylic acid methyl ester

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Technology Process of (1S,2R,4S,5S)-1-Carbamoyl-5-hydroxy-4-iodo-2-phenyl-cyclohexanecarboxylic acid methyl ester

There total 4 articles about (1S,2R,4S,5S)-1-Carbamoyl-5-hydroxy-4-iodo-2-phenyl-cyclohexanecarboxylic acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 190074-03-4
(1S,6R)-1-Carbamoyl-6-phenyl-cyclohex-3-enecarboxylic acid methyl ester

: 190074-05-6
(1S,2R,4S,5S)-1-Carbamoyl-5-hydroxy-4-iodo-2-phenyl-cyclohexanecarboxylic acid methyl ester

Guidance literature:: With water; iodine; In 1,4-dioxane; for 10h; Ambient temperature;
DOI:10.1016/S0957-4166(97)00083-9

Reference yield:

: 162272-50-6
(1S,6R)-1-Cyano-6-phenyl-3-cyclohexene-1-carboxylic acid

: 190074-05-6
(1S,2R,4S,5S)-1-Carbamoyl-5-hydroxy-4-iodo-2-phenyl-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: aq. H₂O₂, NaOH / 72 h / 50 °C

2: CH₂Cl₂; diethyl ether / 0.17 h

3: I₂ / dioxane / 10 h / Ambient temperature

4: H₂O / dioxane / 6 h / Ambient temperature

With sodium hydroxide; water; dihydrogen peroxide; iodine; In 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1016/S0957-4166(97)00083-9

Reference yield:

: (1S,6R)-1-Carbamoyl-6-phenyl-cyclohex-3-enecarboxylic acid

: 190074-05-6
(1S,2R,4S,5S)-1-Carbamoyl-5-hydroxy-4-iodo-2-phenyl-cyclohexanecarboxylic acid methyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: CH₂Cl₂; diethyl ether / 0.17 h

2: I₂ / dioxane / 10 h / Ambient temperature

3: H₂O / dioxane / 6 h / Ambient temperature

With water; iodine; In 1,4-dioxane; diethyl ether; dichloromethane;
DOI:10.1016/S0957-4166(97)00083-9