2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

Base Information

• Chemical Name: 2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide
• CAS No.: 1027504-23-9
• Molecular Formula: C₁₉H₁₃N₅O₄
• Molecular Weight: 375.343

Synonyms:2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

Chemical Property of 2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

Chemical Property:

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Technology Process of 2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

There total 3 articles about 2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid (1025996-25-1) + pyridine-2-carbonyl chloride (29745-44-6) → 2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide (1027504-23-9)

Guidance literature:

2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid; With 1,1'-carbonyldiimidazole; In N,N-dimethyl-formamide; at 80 ℃; for 3h;

pyridine-2-carbonyl chloride; In N,N-dimethyl-formamide; for 18h; Heating;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

5-formyl-2-nitrophenol (704-13-2) → 2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide (1027504-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: nitrobenzene / 18 h / 155 - 160 °C

2.1: 1,1'-carbonyldiimidazole / dimethylformamide / 3 h / 80 °C

2.2: dimethylformamide / 18 h / Heating

With 1,1'-carbonyldiimidazole; In nitrobenzene; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2006.03.014

Reference yield:

3,4-diaminobenzoic acid (619-05-6) → 2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide (1027504-23-9)

Guidance literature:

Multi-step reaction with 2 steps

1.1: nitrobenzene / 18 h / 155 - 160 °C

2.1: 1,1'-carbonyldiimidazole / dimethylformamide / 3 h / 80 °C

2.2: dimethylformamide / 18 h / Heating

With 1,1'-carbonyldiimidazole; In nitrobenzene; N,N-dimethyl-formamide;

DOI:10.1016/j.ejmech.2006.03.014

upstream raw materials:

2-(3-hydroxy-4-nitro-phenyl)-1H-benzoimidazole-5-carboxylic acid

pyridine-2-carbonyl chloride

5-formyl-2-nitrophenol

3,4-diaminobenzoic acid

Downstream raw materials:

2-(4-amino-3-hydroxy-phenyl)-1H-benzoimidazole-5-carboxylic acid pyridin-2-ylamide

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