6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

Base Information

Chemical Name:6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylic acid amide
CAS No.:1542067-15-1
Molecular Formula:C₂₀H₂₀N₄O₂
Molecular Weight:348.404
Hs Code.:

Synonyms:6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

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Chemical Property of 6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

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Technology Process of 6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

There total 3 articles about 6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylic acid amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

: (4-nitrophenyl) 6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylate

: 1542067-15-1
6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

Guidance literature:: With ammonium carbonate; In N,N-dimethyl-formamide; at 40 ℃; for 0.5h;

Reference yield: 72.0%

: 6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylic acid 4-nitrophenyl ester

: 1542067-15-1
6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

Guidance literature:: With ammonium carbonate; In N,N-dimethyl-formamide; at 60 ℃; for 0.5h; Inert atmosphere;
DOI:10.1016/j.bmc.2013.12.031

Reference yield:

: 389621-83-4
(4-(piperidine-1-carbonyl)phenyl)boronic acid

: 1542067-15-1
6-[4-(piperidine-1-carbonyl)phenyl]pyrrolo[2,3-b]pyridine-1-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; sodium hydrogencarbonate / 1,2-dimethoxyethane; water / 1 h / 110 - 115 °C / Inert atmosphere

2: tetrabutylammomium bromide; sodium hydroxide / toluene / 7 h / 40 °C / Inert atmosphere

3: ammonium carbonate / N,N-dimethyl-formamide / 0.5 h / 60 °C / Inert atmosphere

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; tetrabutylammomium bromide; ammonium carbonate; sodium hydrogencarbonate; sodium hydroxide; In 1,2-dimethoxyethane; water; N,N-dimethyl-formamide; toluene; 1: |Suzuki-Miyaura Coupling;
DOI:10.1016/j.bmc.2013.12.031