6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridine-3-carbaldehyde

Base Information

Chemical Name:6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridine-3-carbaldehyde
CAS No.:137586-47-1
Molecular Formula:C₂₅H₂₈FNO
Molecular Weight:377.502
Hs Code.:

Synonyms:6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridine-3-carbaldehyde

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Chemical Property of 6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridine-3-carbaldehyde

Chemical Property:

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Technology Process of 6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridine-3-carbaldehyde

There total 6 articles about 6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridine-3-carbaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 135426-21-0
[6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridin-3-yl]-methanol

: 137586-47-1
6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridine-3-carbaldehyde

Guidance literature:: With oxalyl dichloride; dimethyl sulfoxide; In tetrahydrofuran; dichloromethane; at -78 ℃; for 0.25h;
DOI:10.1021/jm00113a019

Reference yield:

: 459-57-4
4-fluorobenzaldehyde

: 137586-47-1
6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: EtONa / ethanol / 15 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

With lithium aluminium tetrahydride; copper diacetate; oxalyl dichloride; ammonium acetate; sodium ethanolate; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019

Reference yield:

: 1660-04-4
1-acetyladamantane

: 137586-47-1
6-Adamantan-1-yl-4-(4-fluoro-phenyl)-2-isopropyl-pyridine-3-carbaldehyde

Guidance literature:: Multi-step reaction with 5 steps

1: EtONa / ethanol / 15 h / Ambient temperature

2: EtONa / ethanol / 4.5 h / Ambient temperature

3: NH₄OAc, Cu(OAc)2 / acetic acid / 24 h / Heating

4: LiAlH₄ / tetrahydrofuran / 6 h / Ambient temperature

5: oxalyl chloride, DMSO / CH₂Cl₂; tetrahydrofuran / 0.25 h / -78 °C

With lithium aluminium tetrahydride; copper diacetate; oxalyl dichloride; ammonium acetate; sodium ethanolate; dimethyl sulfoxide; In tetrahydrofuran; ethanol; dichloromethane; acetic acid;
DOI:10.1021/jm00113a019