4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Base Information

Chemical Name:4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine
CAS No.:1350545-62-8
Molecular Formula:C₁₈H₂₇N₇
Molecular Weight:341.459
Hs Code.:

Synonyms:4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Suppliers and Price of 4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of 4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Chemical Property:

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

There total 6 articles about 4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 70.6%

: 1350545-39-9
N⁴-isopropyl-N²-(4-(4-methylpiperazin-1-yl)phenyl)-5-nitropyrimidine-2,4-diamine

: 1350545-62-8
4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Guidance literature:: With iron; ammonium chloride; In ethanol; water; at 90 ℃; for 3h;

Reference yield:

: 890094-38-9
2-chloro-N-isopropyl-5-nitropyrimidin-4-amine

: 1350545-62-8
4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1: butan-1-ol / 5 h / 90 °C

2: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 50 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; In methanol; butan-1-ol;
DOI:10.1021/jm301365e

Reference yield:

: 109-01-3
1-methyl-piperazine

: 1350545-62-8
4-isopropylamino-2-(4-(4-methylpiperazin-1-yl)phenylamino)-5-aminopyrimidine

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / dimethyl sulfoxide / 0.5 h / 20 °C

1.2: 6 h / 20 °C

2.1: hydrogen; palladium 10% on activated carbon / ethanol / 9 h / 20 °C

3.1: butan-1-ol / 5 h / 90 °C

4.1: hydrogen; palladium 10% on activated carbon / methanol / 6 h / 50 °C / 760.05 Torr

With palladium 10% on activated carbon; hydrogen; potassium carbonate; In methanol; ethanol; dimethyl sulfoxide; butan-1-ol;
DOI:10.1021/jm301365e