7-phenyl-6-demethoxythebaine

Base Information

• Chemical Name: 7-phenyl-6-demethoxythebaine
• CAS No.: 951656-39-6
• Molecular Formula: C₂₄H₂₃NO₂
• Molecular Weight: 357.452
• Mol file: 951656-39-6.mol

Synonyms:7-phenyl-6-demethoxythebaine

Chemical Property of 7-phenyl-6-demethoxythebaine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 7-phenyl-6-demethoxythebaine

There total 1 articles about 7-phenyl-6-demethoxythebaine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

6-demethoxy-7-bromothebaine (106086-08-2) + phenylboronic acid (98-80-6) → 7-phenyl-6-demethoxythebaine (951656-39-6)

Guidance literature:

With barium dihydroxide; bis-triphenylphosphine-palladium(II) chloride; In 1,4-dioxane; water; for 0.5h; Heating;

DOI:10.1080/00397910701462773

Reference yield: 88.0%

7-phenyl-6-demethoxythebaine (951656-39-6) → 3-phenylapocodeine (951656-46-5)

Guidance literature:

With methanesulfonic acid; at 0 ℃; for 0.333333h;

DOI:10.1080/00397910701462773

Reference yield:

7-phenyl-6-demethoxythebaine (951656-39-6) → 3-phenylapomorphine

Guidance literature:

Multi-step reaction with 2 steps

1: 88 percent / methanesulfonic acid / 0.33 h / 0 °C

2: methionine; methanesulfonic acid / 4 h / 90 °C

With methanesulfonic acid; DL-methionine;

DOI:10.1080/00397910701462773

upstream raw materials:

6-demethoxy-7-bromothebaine

phenylboronic acid

Downstream raw materials:

3-phenylapocodeine