6-{2-[(diisopropoxyphosphoryl)methoxy]ethoxy}-4-hydroxy-2-phenylpyrimidine

Base Information

Chemical Name:6-{2-[(diisopropoxyphosphoryl)methoxy]ethoxy}-4-hydroxy-2-phenylpyrimidine
CAS No.:1333147-32-2
Molecular Formula:C₁₉H₂₇N₂O₆P
Molecular Weight:410.407
Hs Code.:

Synonyms:6-{2-[(diisopropoxyphosphoryl)methoxy]ethoxy}-4-hydroxy-2-phenylpyrimidine

Suppliers and Price of 6-{2-[(diisopropoxyphosphoryl)methoxy]ethoxy}-4-hydroxy-2-phenylpyrimidine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 6-{2-[(diisopropoxyphosphoryl)methoxy]ethoxy}-4-hydroxy-2-phenylpyrimidine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 6-{2-[(diisopropoxyphosphoryl)methoxy]ethoxy}-4-hydroxy-2-phenylpyrimidine

There total 2 articles about 6-{2-[(diisopropoxyphosphoryl)methoxy]ethoxy}-4-hydroxy-2-phenylpyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1160512-82-2
6-[2-(diisopropoxyphosphorylmethoxy)ethoxy]-4-hydroxy-2-(methylsulfanyl)pyrimidine

: 98-80-6
phenylboronic acid

: 1333147-32-2
6-{2-[(diisopropoxyphosphoryl)methoxy]ethoxy}-4-hydroxy-2-phenylpyrimidine

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; In tetrahydrofuran; at 60 ℃; for 24h;
DOI:10.1016/j.tet.2011.07.040

Reference yield:

: 151965-56-9
diisopropyl 2-(chloroethoxy)methylphosphonate

: 1333147-32-2
6-{2-[(diisopropoxyphosphoryl)methoxy]ethoxy}-4-hydroxy-2-phenylpyrimidine

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / dimethyl sulfoxide; mineral oil / 0.5 h / 60 °C / Inert atmosphere

1.2: 8 h / 120 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate / tetrahydrofuran / 24 h / 60 °C

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(I) 2-hydroxy-3-methylbenzoate; sodium hydride; In tetrahydrofuran; dimethyl sulfoxide; mineral oil; 2.1: Liebeskind-Srogl cross-coupling;
DOI:10.1016/j.tet.2011.07.040