1-(2-Amino-6-{[2-({7-(2,4-dichlorophenyl)-2-[1-(propan-2-yl)piperidin-4-yl][1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridin-3-yl)propan-1-one

Base Information

Chemical Name:1-(2-Amino-6-{[2-({7-(2,4-dichlorophenyl)-2-[1-(propan-2-yl)piperidin-4-yl][1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridin-3-yl)propan-1-one
CAS No.:1196678-00-8
Molecular Formula:C₂₉H₃₅Cl₂N₉O
Molecular Weight:596.563
Hs Code.:

Synonyms:1-(2-Amino-6-{[2-({7-(2,4-dichlorophenyl)-2-[1-(propan-2-yl)piperidin-4-yl][1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridin-3-yl)propan-1-one

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Chemical Property of 1-(2-Amino-6-{[2-({7-(2,4-dichlorophenyl)-2-[1-(propan-2-yl)piperidin-4-yl][1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridin-3-yl)propan-1-one

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Technology Process of 1-(2-Amino-6-{[2-({7-(2,4-dichlorophenyl)-2-[1-(propan-2-yl)piperidin-4-yl][1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridin-3-yl)propan-1-one

There total 10 articles about 1-(2-Amino-6-{[2-({7-(2,4-dichlorophenyl)-2-[1-(propan-2-yl)piperidin-4-yl][1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridin-3-yl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1196678-32-6
5-Chloro-7-(2,4-dichlorophenyl)-2-[1-(propan-2-yl)piperidin-4-yl][1,2,4]triazolo[1,5-c]pyrimidine

: 1-{2-amino-6-[(2-aminoethyl)amino]pyridin-3-yl}propan-1-one hydrochloride

: 1196678-00-8
1-(2-Amino-6-{[2-({7-(2,4-dichlorophenyl)-2-[1-(propan-2-yl)piperidin-4-yl][1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridin-3-yl)propan-1-one

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In dimethyl sulfoxide; at 120 ℃; for 0.5h; Microwave irradiation;

Reference yield:

: 154348-17-1
ethyl 1-isopropylpiperidine-4-carboxylate

: 1196678-00-8
1-(2-Amino-6-{[2-({7-(2,4-dichlorophenyl)-2-[1-(propan-2-yl)piperidin-4-yl][1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridin-3-yl)propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: hydrazine hydrate / ethanol / 16 h / Reflux

2.1: 1-methyl-pyrrolidin-2-one / 3 h / 160 °C

3.1: trichlorophosphate; N-benzyl-N,N,N-triethylammonium chloride / 2.5 h / 120 °C

3.2: pH 7

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 120 °C / Microwave irradiation

With N-benzyl-N,N,N-triethylammonium chloride; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; trichlorophosphate; In 1-methyl-pyrrolidin-2-one; ethanol; dimethyl sulfoxide;

Reference yield:

: 159603-71-1
t-butyl N-(6-chloro-2-pyridinyl)carbamate

: 1196678-00-8
1-(2-Amino-6-{[2-({7-(2,4-dichlorophenyl)-2-[1-(propan-2-yl)piperidin-4-yl][1,2,4]triazolo[1,5-c]-pyrimidin-5-yl}amino)ethyl]amino}pyridin-3-yl)propan-1-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / -50 - 0 °C / Inert atmosphere

1.2: 1 h / -40 °C

2.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.75 h / 90 °C / Microwave irradiation

3.1: hydrogenchloride / 1,4-dioxane / 20 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / dimethyl sulfoxide / 0.5 h / 120 °C / Microwave irradiation

With hydrogenchloride; n-butyllithium; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; 1,4-dioxane; hexane; dimethyl sulfoxide;