(E)-3-(4-((6-hydroxy-2-(2-isopropylphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

Base Information

Chemical Name:(E)-3-(4-((6-hydroxy-2-(2-isopropylphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid
CAS No.:1622307-16-7
Molecular Formula:C₂₆H₂₂O₄S
Molecular Weight:430.524
Hs Code.:

Synonyms:(E)-3-(4-((6-hydroxy-2-(2-isopropylphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

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Chemical Property of (E)-3-(4-((6-hydroxy-2-(2-isopropylphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

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Technology Process of (E)-3-(4-((6-hydroxy-2-(2-isopropylphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

There total 10 articles about (E)-3-(4-((6-hydroxy-2-(2-isopropylphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 1622307-62-3
(E)-methyl 3-(4-((6-hydroxy-2-(2-isopropylphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylate

: 1622307-16-7
(E)-3-(4-((6-hydroxy-2-(2-isopropylphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

Guidance literature:: With water; lithium hydroxide; In ethanol; at 20 ℃; for 5h;

Reference yield: 35.0%

: 1622308-50-2
(E)-tert-butyl 3-(4-((2-(2-isopropylphenyl)-6-methoxybenzo[b]thiophen-3-yl)oxy)phenyl)acrylate

: 1622307-16-7
(E)-3-(4-((6-hydroxy-2-(2-isopropylphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

Guidance literature:: With boron tribromide; In dichloromethane; at 0 ℃; for 1h;
DOI:10.1021/acs.jmedchem.7b01682

Reference yield:

: 1622308-31-9
3-(4-bromophenoxy)-6-methoxybenzo[b]thiophene

: 1622307-16-7
(E)-3-(4-((6-hydroxy-2-(2-isopropylphenyl)benzo[b]thiophen-3-yl)oxy)phenyl)acrylic acid

Guidance literature:: Multi-step reaction with 4 steps

1: bis-triphenylphosphine-palladium(II) chloride; triethylamine / N,N-dimethyl-formamide / 1 h / 120 °C / Microwave irradiation

2: Trimethylacetic acid; potassium carbonate; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II) / N,N-dimethyl acetamide / 2 h / 150 °C / Inert atmosphere; Sealed tube

3: boron tribromide / dichloromethane; n-heptane / 1 h / 0 °C

4: lithium hydroxide; water / ethanol / 5 h / 20 °C

With bis-triphenylphosphine-palladium(II) chloride; chloro[2-(dicyclohexylphosphino)-3,6-dimethoxy-2′,4′,6′-tri-1-propyl-1,1′-biphenyl][2-(2-aminoethyl)phenyl]palladium(II); water; boron tribromide; potassium carbonate; triethylamine; lithium hydroxide; Trimethylacetic acid; In ethanol; n-heptane; dichloromethane; N,N-dimethyl acetamide; N,N-dimethyl-formamide;