tert-butyl 4-(4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)-3-(2-(tosyloxy)ethoxy)phenoxy)piperidine-1-carboxylate

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Chemical Name:tert-butyl 4-(4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)-3-(2-(tosyloxy)ethoxy)phenoxy)piperidine-1-carboxylate
CAS No.:1454663-25-2
Molecular Formula:C₄₁H₅₁N₃O₉S
Molecular Weight:761.937
Hs Code.:

Synonyms:tert-butyl 4-(4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)-3-(2-(tosyloxy)ethoxy)phenoxy)piperidine-1-carboxylate

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Chemical Property of tert-butyl 4-(4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)-3-(2-(tosyloxy)ethoxy)phenoxy)piperidine-1-carboxylate

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Technology Process of tert-butyl 4-(4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)-3-(2-(tosyloxy)ethoxy)phenoxy)piperidine-1-carboxylate

There total 3 articles about tert-butyl 4-(4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)-3-(2-(tosyloxy)ethoxy)phenoxy)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

: 1454663-20-7
tert-butyl 4-(3-hydroxy-4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)phenoxy)piperidine-1-carboxylate

: 6315-52-2
1,2-bis-tosyloxyethane

: 1454663-25-2
tert-butyl 4-(4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)-3-(2-(tosyloxy)ethoxy)phenoxy)piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 19h; Inert atmosphere;
DOI:10.1016/j.bmcl.2013.07.045

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1454663-25-2
tert-butyl 4-(4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)-3-(2-(tosyloxy)ethoxy)phenoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane / 1 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere

With caesium carbonate; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.045

Reference yield:

: 1369358-07-5
1-(1-(2-(2-hydroxy-4-(piperidin-4-yloxy)phenyl)acetyl)piperidin-4-yl)-3,4-dihydroquinolin-2(1H)-one hydrochloride

: 1454663-25-2
tert-butyl 4-(4-(2-oxo-2-(4-(2-oxo-3,4-dihydroquinolin-1(2H)-yl)piperidin-1-yl)ethyl)-3-(2-(tosyloxy)ethoxy)phenoxy)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / 1,4-dioxane / 1 h / 20 °C

2: caesium carbonate / N,N-dimethyl-formamide / 19 h / 20 °C / Inert atmosphere

With caesium carbonate; sodium hydroxide; In 1,4-dioxane; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2013.07.045