N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid

Base Information

Chemical Name:N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid
CAS No.:118141-90-5
Molecular Formula:C₂₅H₂₅N₅O₆
Molecular Weight:491.503
Hs Code.:

N-<4-<N-<<3,4-Dihydro-2-(methylamino)-4-oxo-6-quinazolinyl>methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid

Synonyms:N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid

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Technology Process of N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid

There total 5 articles about N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 118111-60-7
Diethyl N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamate

: 118141-90-5
N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid

Guidance literature:: With sodium hydroxide; In ethanol; water; for 4h; Ambient temperature;
DOI:10.1021/jm00123a010

Reference yield:

: 76858-72-5
diethyl N-(4-(prop-2-ynylamino)benzoyl)-L-glutamate

: 118141-90-5
N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / CaCO₃ / dimethylformamide / 16 h / 60 °C

2: 91 percent / various solvent(s); ethanol / 6 h / 100 °C

3: 95 percent / 1 N aq. NaOH / ethanol; H₂O / 4 h / Ambient temperature

With sodium hydroxide; calcium carbonate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a010

Reference yield:

: 118111-59-4
6-Bromomethyl-2-chloro-3H-quinazolin-4-one

: 118141-90-5
N-<4-methyl>-N-prop-2-ynylamino>benzoyl>-L-glutamic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 54 percent / CaCO₃ / dimethylformamide / 16 h / 60 °C

2: 91 percent / various solvent(s); ethanol / 6 h / 100 °C

3: 95 percent / 1 N aq. NaOH / ethanol; H₂O / 4 h / Ambient temperature

With sodium hydroxide; calcium carbonate; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1021/jm00123a010