5-(3-chloro-4-fluorophenyl)-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)piperidin-2-one

Base Information

Chemical Name:5-(3-chloro-4-fluorophenyl)-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)piperidin-2-one
CAS No.:1231957-83-7
Molecular Formula:C₁₈H₂₃ClFNO₃
Molecular Weight:355.837
Hs Code.:

Synonyms:5-(3-chloro-4-fluorophenyl)-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)piperidin-2-one

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5-(3-chloro-4-fluorophenyl)-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)piperidin-2-one

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Technology Process of 5-(3-chloro-4-fluorophenyl)-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)piperidin-2-one

There total 1 articles about 5-(3-chloro-4-fluorophenyl)-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)piperidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.9%

: 1231957-82-6
ethyl 4-(3-chloro-4-fluorophenyl)-4-cyano-6-(tetrahydro-2H-pyran-2-yloxy)hexanoate

: 1231957-83-7
5-(3-chloro-4-fluorophenyl)-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)piperidin-2-one

Guidance literature:: With ammonium hydroxide; hydrogen; Raney nickel 2800; In ethanol; at 40 - 55 ℃; for 36h; under 2585.81 Torr;

Reference yield: 53.2%

: 1231957-83-7
5-(3-chloro-4-fluorophenyl)-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)piperidin-2-one

: 1231956-14-1
2-(3-(3-chloro-4-fluorophenyl)piperidin-3-yl)ethanol

Guidance literature:: 5-(3-chloro-4-fluorophenyl)-5-(2-(tetrahydro-2H-pyran-2-yloxy)ethyl)piperidin-2-one; With borane-THF; In tetrahydrofuran; at 70 ℃; for 1h; Inert atmosphere;

With hydrogenchloride; methanol; water; In tetrahydrofuran; at 0 - 60 ℃;

With sodium carbonate; In water; at 18 - 25 ℃; pH=9;