isopropyl 4-(3-(2-benzyl-1,2,3,4-tetrahydro-2,6-naphthyridin-5-yloxy)propyl)piperidine-1-carboxylate

Base Information

Chemical Name:isopropyl 4-(3-(2-benzyl-1,2,3,4-tetrahydro-2,6-naphthyridin-5-yloxy)propyl)piperidine-1-carboxylate
CAS No.:1182323-52-9
Molecular Formula:C₂₇H₃₇N₃O₃
Molecular Weight:451.609
Hs Code.:

Synonyms:isopropyl 4-(3-(2-benzyl-1,2,3,4-tetrahydro-2,6-naphthyridin-5-yloxy)propyl)piperidine-1-carboxylate

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Chemical Property of isopropyl 4-(3-(2-benzyl-1,2,3,4-tetrahydro-2,6-naphthyridin-5-yloxy)propyl)piperidine-1-carboxylate

Chemical Property:

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Technology Process of isopropyl 4-(3-(2-benzyl-1,2,3,4-tetrahydro-2,6-naphthyridin-5-yloxy)propyl)piperidine-1-carboxylate

There total 3 articles about isopropyl 4-(3-(2-benzyl-1,2,3,4-tetrahydro-2,6-naphthyridin-5-yloxy)propyl)piperidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 919360-47-7
4-(3-methanesulfonyloxypropyl)piperidine-1-carboxylic acid isopropyl ester

: 601514-62-9
6-benzyl-5,6,7,8-tetrahydro-2,6-naphthyridin-1(2H)-one

: 1182323-49-4
isopropyl 4-(3-(6-benzyl-5,6,7,8-tetrahydro-1-oxo-2,6-naphthyridin-2(5H)-yl)propyl)piperidine-1-carboxylate

: 1182323-52-9
isopropyl 4-(3-(2-benzyl-1,2,3,4-tetrahydro-2,6-naphthyridin-5-yloxy)propyl)piperidine-1-carboxylate

Guidance literature:: With caesium carbonate; In acetonitrile; at 65 ℃;

Reference yield:

: 7584-05-6
3-methyl-4-cyanopyridine

: 1182323-52-9
isopropyl 4-(3-(2-benzyl-1,2,3,4-tetrahydro-2,6-naphthyridin-5-yloxy)propyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: N,N-dimethyl-formamide / 18 h / Reflux

2.1: water; hydrogen bromide / ethanol / 19 h / Reflux

3.1: acetonitrile / 2 h / Inert atmosphere; Reflux

3.2: 17.5 h / 0 - 20 °C

4.1: caesium carbonate / acetonitrile / 65 °C

With water; hydrogen bromide; caesium carbonate; In ethanol; N,N-dimethyl-formamide; acetonitrile;

Reference yield:

: 1003-73-2
3-picoline-N-oxide

: 1182323-52-9
isopropyl 4-(3-(2-benzyl-1,2,3,4-tetrahydro-2,6-naphthyridin-5-yloxy)propyl)piperidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethyl iodide / dichloromethane / Reflux

1.2: 2 h / 50 - 60 °C

2.1: N,N-dimethyl-formamide / 18 h / Reflux

3.1: water; hydrogen bromide / ethanol / 19 h / Reflux

4.1: acetonitrile / 2 h / Inert atmosphere; Reflux

4.2: 17.5 h / 0 - 20 °C

5.1: caesium carbonate / acetonitrile / 65 °C

With water; hydrogen bromide; caesium carbonate; ethyl iodide; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;