2,4-Pyrimidinediamine,5-[[3,5-dimethoxy-4-[3-[[4-[(4-nitrophenyl)sulfonyl]phenyl]amino]propoxy]phenyl]methyl]-

Base Information

• Chemical Name: 2,4-Pyrimidinediamine,5-[[3,5-dimethoxy-4-[3-[[4-[(4-nitrophenyl)sulfonyl]phenyl]amino]propoxy]phenyl]methyl]-
• CAS No.: 111452-84-7
• Molecular Formula: C28H30 N6 O7 S
• Molecular Weight: 594.648
• Mol file: 111452-84-7.mol

Synonyms:K 122; K122 (bactericide)

Chemical Property of 2,4-Pyrimidinediamine,5-[[3,5-dimethoxy-4-[3-[[4-[(4-nitrophenyl)sulfonyl]phenyl]amino]propoxy]phenyl]methyl]-

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,4-Pyrimidinediamine,5-[[3,5-dimethoxy-4-[3-[[4-[(4-nitrophenyl)sulfonyl]phenyl]amino]propoxy]phenyl]methyl]-

There total 4 articles about 2,4-Pyrimidinediamine,5-[[3,5-dimethoxy-4-[3-[[4-[(4-nitrophenyl)sulfonyl]phenyl]amino]propoxy]phenyl]methyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

4--4'-nitrodiphenylsulphone (111453-08-8) + 2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine (21253-58-7) → 5-(3,5-Dimethoxy-4-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine (111452-84-7)

Guidance literature:

With sodium; In 2-methoxy-ethanol; at 60 ℃; for 8h;

DOI:10.1016/0223-5234(92)90007-N

Reference yield:

4'-nitro-4-N-tosylaminodiphenyl sulfide (111453-03-3) → 5-(3,5-Dimethoxy-4-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine (111452-84-7)

Guidance literature:

Multi-step reaction with 4 steps

1: 82 percent / CuI, aq. KOH / ethanol / 2 h / Heating

2: 94 percent / concd H₂O₂, glacial AcOH / 4 h / 65 °C

3: 97 percent / concd H₂SO₄ / 1 h / Ambient temperature

4: 51 percent / Na / 2-methoxy-ethanol / 8 h / 60 °C

With potassium hydroxide; copper(l) iodide; sulfuric acid; dihydrogen peroxide; sodium; acetic acid; In ethanol; 2-methoxy-ethanol;

DOI:10.1016/0223-5234(92)90007-N

Reference yield:

4--4'-nitrodiphenylsulphide (111453-06-6) → 5-(3,5-Dimethoxy-4-{3-[4-(4-nitro-benzenesulfonyl)-phenylamino]-propoxy}-benzyl)-pyrimidine-2,4-diamine (111452-84-7)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / concd H₂O₂, glacial AcOH / 4 h / 65 °C

2: 97 percent / concd H₂SO₄ / 1 h / Ambient temperature

3: 51 percent / Na / 2-methoxy-ethanol / 8 h / 60 °C

With sulfuric acid; dihydrogen peroxide; sodium; acetic acid; In 2-methoxy-ethanol;

DOI:10.1016/0223-5234(92)90007-N

upstream raw materials:

4--4'-nitrodiphenylsulphone

2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine

4'-nitro-4-N-tosylaminodiphenyl sulfide

4--4'-nitrodiphenylsulphide

Downstream raw materials:

2,4-diamino-5-<4-<3-(4''-aminophenyl-4'-sulphonylphenylamino)propoxy>-3,5-dimethoxybenzyl>pyrimidine