7-deoxy-7-epi-7-(4-(4-methylmorpholin-2-yl)phenylthio)lincom

Base Information

Chemical Name:7-deoxy-7-epi-7-(4-(4-methylmorpholin-2-yl)phenylthio)lincom
CAS No.:941585-14-4
Molecular Formula:C₂₉H₄₇N₃O₆S₂
Molecular Weight:597.841
Hs Code.:

Synonyms:7-deoxy-7-epi-7-(4-(4-methylmorpholin-2-yl)phenylthio)lincom

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Chemical Property of 7-deoxy-7-epi-7-(4-(4-methylmorpholin-2-yl)phenylthio)lincom

Chemical Property:

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Technology Process of 7-deoxy-7-epi-7-(4-(4-methylmorpholin-2-yl)phenylthio)lincom

There total 14 articles about 7-deoxy-7-epi-7-(4-(4-methylmorpholin-2-yl)phenylthio)lincom which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₄F₃NO₄S

: 23474-34-2
7(S)-7-deoxy-7-mercaptolincomycin

: 941585-14-4
7-deoxy-7-epi-7-(4-(4-methylmorpholin-2-yl)phenylthio)lincom

Guidance literature:: With N-ethyl-N,N-diisopropylamine; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; for 5h; Heating / reflux;

Reference yield:

: 104-14-3,1915-83-9
octopamine

: 941585-14-4
7-deoxy-7-epi-7-(4-(4-methylmorpholin-2-yl)phenylthio)lincom

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / 1,4-dioxane; water / 0.08 h / 20 °C

1.2: 17 h / 20 °C

2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 20 °C

2.2: 21 h / 20 - 100 °C

3.1: hydrogenchloride; methanol; water / 0.5 h / 20 °C

4.1: cyanomethylenetributyl-phosphorane / toluene / 1.33 h / Heating / reflux

5.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C

5.2: 3.5 h / 20 °C

6.1: acetic acid / sodium tris(acetoxy)borohydride / methanol; water / 0.25 h / 20 °C

7.1: 2,6-dimethylpyridine / dichloromethane / 0.17 h / 0 °C

7.2: 0.25 h / 0 °C

8.1: N-ethyl-N,N-diisopropylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 5 h / Heating / reflux

With 2,6-dimethylpyridine; hydrogenchloride; methanol; sodium hydroxide; water; sodium hydride; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; cyanomethylenetributyl-phosphorane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium tris(acetoxy)borohydride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 4-(1-hydroxy-2-(N-(2-hydroxyethyl)-2-nitrophenylsulfonamido)ethyl)phenyl 2-nitrobenzenesulfonate

: 941585-14-4
7-deoxy-7-epi-7-(4-(4-methylmorpholin-2-yl)phenylthio)lincom

Guidance literature:: Multi-step reaction with 5 steps

1.1: cyanomethylenetributyl-phosphorane / toluene / 1.33 h / Heating / reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 0.08 h / 20 °C

2.2: 3.5 h / 20 °C

3.1: acetic acid / sodium tris(acetoxy)borohydride / methanol; water / 0.25 h / 20 °C

4.1: 2,6-dimethylpyridine / dichloromethane / 0.17 h / 0 °C

4.2: 0.25 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / 1,4-dioxane / 5 h / Heating / reflux

With 2,6-dimethylpyridine; potassium carbonate; acetic acid; N-ethyl-N,N-diisopropylamine; cyanomethylenetributyl-phosphorane; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium tris(acetoxy)borohydride; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; methanol; dichloromethane; water; N,N-dimethyl-formamide; toluene;