N-[4-(3-iodo-4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane

Base Information

• Chemical Name: N-[4-(3-iodo-4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane
• CAS No.: 387357-14-4
• Molecular Formula: C₂₅H₃₀ClIN₂O₂
• Molecular Weight: 552.883
• Mol file: 387357-14-4.mol

Synonyms:N-[4-(3-iodo-4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane

Chemical Property of N-[4-(3-iodo-4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-[4-(3-iodo-4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane

There total 12 articles about N-[4-(3-iodo-4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

N-[4-(4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane (387357-13-3) → N-[4-(3-iodo-4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane (387357-14-4)

Guidance literature:

With Iodine monochloride; acetic acid; at 20 ℃; for 3h;

DOI:10.1021/jm0101904

Reference yield:

4-(4-nitrophenyl)butanoic acid (5600-62-4) → N-[4-(3-iodo-4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane (387357-14-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 98 percent / BH₃*SMe₂ / tetrahydrofuran / 1 h

2: 94 percent / triphenylphosphine; carbon tetrabromide / acetonitrile / 1 h / 20 °C

3: 94 percent / K₂CO₃ / dimethylformamide

4: 70 percent / H₂ / 10percent Pd/C / methanol; ethyl acetate / 3 h / 2068.65 Torr

5: 60 percent / ICl; glacial acetic acid / 3 h / 20 °C

With carbon tetrabromide; dimethylsulfide borane complex; hydrogen; Iodine monochloride; potassium carbonate; acetic acid; triphenylphosphine; 10percent Pd/C; In tetrahydrofuran; methanol; ethyl acetate; N,N-dimethyl-formamide; acetonitrile;

DOI:10.1021/jm0101904

Reference yield:

1-(4-bromobutyl)-4-nitrobenzene (99359-34-9) → N-[4-(3-iodo-4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane (387357-14-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 94 percent / K₂CO₃ / dimethylformamide

2: 70 percent / H₂ / 10percent Pd/C / methanol; ethyl acetate / 3 h / 2068.65 Torr

3: 60 percent / ICl; glacial acetic acid / 3 h / 20 °C

With hydrogen; Iodine monochloride; potassium carbonate; acetic acid; 10percent Pd/C; In methanol; ethyl acetate; N,N-dimethyl-formamide;

DOI:10.1021/jm0101904

upstream raw materials:

N-[4-(4-aminophenyl)butyl]-2β-carbomethoxy-3β-(4-chlorophenyl)tropane

4-(4-nitrophenyl)butanoic acid

1-(4-bromobutyl)-4-nitrobenzene

4-(4-nitrophenyl)-1-butanol