2-[N¹-(pentafluorophenoxycarbonyl)-N²-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone

Base Information

• Chemical Name: 2-[N¹-(pentafluorophenoxycarbonyl)-N²-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone
• CAS No.: 255873-71-3
• Molecular Formula: C₁₅H₁₇F₅N₂O₆S
• Molecular Weight: 448.368
• Mol file: 255873-71-3.mol

Synonyms:2-[N¹-(pentafluorophenoxycarbonyl)-N²-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone

Chemical Property of 2-[N¹-(pentafluorophenoxycarbonyl)-N²-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-[N¹-(pentafluorophenoxycarbonyl)-N²-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone

There total 3 articles about 2-[N¹-(pentafluorophenoxycarbonyl)-N²-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

bis(pentafluorophenyl)carbonate (59483-84-0) + 2-[N2-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone (255873-70-2) → 2-[N1-(pentafluorophenoxycarbonyl)-N2-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone (255873-71-3)

Guidance literature:

With pyridine; In tetrahydrofuran;

DOI:10.1021/jo9915123

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) → 2-[N1-(pentafluorophenoxycarbonyl)-N2-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone (255873-71-3)

Guidance literature:

Multi-step reaction with 3 steps

1: 1.75 g / 4-(dimethylamino)pyridine / acetonitrile

2: 97 percent / hydrogen / Pd/C / methanol / 1.33 h

3: 86 percent / pyridine / tetrahydrofuran

With pyridine; dmap; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; acetonitrile; 1: Acylation / 2: Catalytic hydrogenation / 3: Acylation;

DOI:10.1021/jo9915123

Reference yield:

2-[N1-(carbobenzyloxy)-N2-(carbobenzyloxy)-N2-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone (255873-68-8) → 2-[N1-(pentafluorophenoxycarbonyl)-N2-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone (255873-71-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 97 percent / hydrogen / Pd/C / methanol / 1.33 h

2: 86 percent / pyridine / tetrahydrofuran

With pyridine; hydrogen; palladium on activated charcoal; In tetrahydrofuran; methanol; 1: Catalytic hydrogenation / 2: Acylation;

DOI:10.1021/jo9915123

upstream raw materials:

bis(pentafluorophenyl)carbonate

2-[N²-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone

di-tert-butyl dicarbonate

2-[N¹-(carbobenzyloxy)-N²-(carbobenzyloxy)-N²-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone

Downstream raw materials:

2-[N¹-phenethylamidohydrazido] 2-[N²-(tert-butoxycarbonyl)hydrazino]ethyl methyl sulfone