4a-allyl-6-(4-(trifluoromethyl)phenyl)-2,3,4,4a-tetrahydro-1H-carbazole

Base Information

Chemical Name:4a-allyl-6-(4-(trifluoromethyl)phenyl)-2,3,4,4a-tetrahydro-1H-carbazole
CAS No.:1423039-49-9
Molecular Formula:C₂₂H₂₀F₃N
Molecular Weight:355.403
Hs Code.:

Synonyms:4a-allyl-6-(4-(trifluoromethyl)phenyl)-2,3,4,4a-tetrahydro-1H-carbazole

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Chemical Property of 4a-allyl-6-(4-(trifluoromethyl)phenyl)-2,3,4,4a-tetrahydro-1H-carbazole

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Technology Process of 4a-allyl-6-(4-(trifluoromethyl)phenyl)-2,3,4,4a-tetrahydro-1H-carbazole

There total 2 articles about 4a-allyl-6-(4-(trifluoromethyl)phenyl)-2,3,4,4a-tetrahydro-1H-carbazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 1423039-24-0
allyl 6-bromo-3,4-dihydro-1H-carbazole-9(2H)-carboxylate

: 128796-39-4
4-trifluoromethylphenylboronic acid

: 1423039-49-9
4a-allyl-6-(4-(trifluoromethyl)phenyl)-2,3,4,4a-tetrahydro-1H-carbazole

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethyl borane; In hexane; dichloromethane; at 50 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol400110c

Reference yield:

: 21865-50-9
6-bromo-1,2,3,4-tetrahydro-9H-carbazole

: 1423039-49-9
4a-allyl-6-(4-(trifluoromethyl)phenyl)-2,3,4,4a-tetrahydro-1H-carbazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere

1.2: 16 h / 0 - 20 °C / Inert atmosphere

2.1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethyl borane / dichloromethane; hexane / 16 h / 50 °C / Inert atmosphere

With tetrakis(triphenylphosphine) palladium⁽⁰⁾; triethyl borane; sodium hydride; In hexane; dichloromethane; N,N-dimethyl-formamide; 2.1: |Suzuki-Miyaura Coupling;
DOI:10.1021/ol400110c