Technology Process of 1-((1R,3S)-3-(benzyloxy)-1-methylcyclopentyl)-4-methylbenzene
There total 8 articles about 1-((1R,3S)-3-(benzyloxy)-1-methylcyclopentyl)-4-methylbenzene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sodium tetrahydroborate; calcium chloride / ethanol / 2.5 h / 0 °C
2.1: triethylamine / dichloromethane / 6 h / 0 °C / Inert atmosphere
3.1: sodium iodide / acetone / 4 h / 70 °C / Inert atmosphere
4.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
4.2: 12.33 h / 0 - 20 °C
5.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere
6.1: hydrazine hydrate; sodium hydroxide / ethylene glycol / 24 h / 180 °C
With
sodium tetrahydroborate; sodium hydride; diisobutylaluminium hydride; hydrazine hydrate; triethylamine; sodium iodide; calcium chloride; sodium hydroxide;
In
ethanol; dichloromethane; ethylene glycol; N,N-dimethyl-formamide; acetone; toluene;
DOI:10.1016/j.tetasy.2012.10.004
DOI:10.1016/j.tetasy.2012.10.004
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C
1.2: 12.33 h / 0 - 20 °C
2.1: diisobutylaluminium hydride / dichloromethane; toluene / 1 h / -78 °C / Inert atmosphere
3.1: hydrazine hydrate; sodium hydroxide / ethylene glycol / 24 h / 180 °C
With
sodium hydride; diisobutylaluminium hydride; hydrazine hydrate; sodium hydroxide;
In
dichloromethane; ethylene glycol; N,N-dimethyl-formamide; toluene;
DOI:10.1016/j.tetasy.2012.10.004
DOI:10.1016/j.tetasy.2012.10.004