N-allyl-N-(tert-butyloxycarbonyl) 4-methyl-4-nitro-5-phenyl-5-(2-tetrahydropyranoxy)pentylamine

Base Information

Chemical Name:N-allyl-N-(tert-butyloxycarbonyl) 4-methyl-4-nitro-5-phenyl-5-(2-tetrahydropyranoxy)pentylamine
CAS No.:350036-83-8
Molecular Formula:C₂₅H₃₈N₂O₆
Molecular Weight:462.587
Hs Code.:

Synonyms:N-allyl-N-(tert-butyloxycarbonyl) 4-methyl-4-nitro-5-phenyl-5-(2-tetrahydropyranoxy)pentylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-allyl-N-(tert-butyloxycarbonyl) 4-methyl-4-nitro-5-phenyl-5-(2-tetrahydropyranoxy)pentylamine

Chemical Property:

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Technology Process of N-allyl-N-(tert-butyloxycarbonyl) 4-methyl-4-nitro-5-phenyl-5-(2-tetrahydropyranoxy)pentylamine

There total 10 articles about N-allyl-N-(tert-butyloxycarbonyl) 4-methyl-4-nitro-5-phenyl-5-(2-tetrahydropyranoxy)pentylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: allyl-[4-methyl-4-nitro-5-phenyl-5-(tetrahydro-pyran-2-yloxy)-pentyl]-amine

: 350036-83-8
N-allyl-N-(tert-butyloxycarbonyl) 4-methyl-4-nitro-5-phenyl-5-(2-tetrahydropyranoxy)pentylamine

Guidance literature:: With triethylamine; In tetrahydrofuran; at 20 ℃;
DOI:10.1021/ol015965h DOI:10.1021/ja035639s

Reference yield:

: 26251-08-1,26251-09-2,38316-08-4,38316-09-5,6343-57-3
2-nitro-1-phenylpropan-1-ol

: 350036-83-8
N-allyl-N-(tert-butyloxycarbonyl) 4-methyl-4-nitro-5-phenyl-5-(2-tetrahydropyranoxy)pentylamine

Guidance literature:: Multi-step reaction with 6 steps

1: 99 percent / pyridinium p-toluenesulfonate / CH₂Cl₂ / 20 °C

2: 84 percent / DBU / acetonitrile / 20 °C

3: 97 percent / LiAlH₄ / diethyl ether / 2 h / -42 °C

4: 71 percent / triphenylphosphine; imidazole; iodine / diethyl ether; acetonitrile / 20 °C

5: diethyl ether / Heating

6: 559 mg / triethylamine / tetrahydrofuran / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; iodine; pyridinium p-toluenesulfonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; dichloromethane; acetonitrile;
DOI:10.1021/ja035639s

Reference yield:

: 350036-74-7
1-phenyl-1-(2-tetrahydropyranoxy)-2-nitropropanol

: 350036-83-8
N-allyl-N-(tert-butyloxycarbonyl) 4-methyl-4-nitro-5-phenyl-5-(2-tetrahydropyranoxy)pentylamine

Guidance literature:: Multi-step reaction with 5 steps

1: 84 percent / DBU / acetonitrile / 20 °C

2: 97 percent / LiAlH₄ / diethyl ether / 2 h / -42 °C

3: 71 percent / triphenylphosphine; imidazole; iodine / diethyl ether; acetonitrile / 20 °C

4: diethyl ether / Heating

5: 559 mg / triethylamine / tetrahydrofuran / 20 °C

With 1H-imidazole; lithium aluminium tetrahydride; iodine; 1,8-diazabicyclo[5.4.0]undec-7-ene; triethylamine; triphenylphosphine; In tetrahydrofuran; diethyl ether; acetonitrile;
DOI:10.1021/ja035639s