(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)butyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Base Information

Chemical Name:(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)butyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione
CAS No.:1213255-08-3
Molecular Formula:C₂₄H₃₁N₅O₃
Molecular Weight:437.542
Hs Code.:

Synonyms:(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)butyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

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Chemical Property of (S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)butyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

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Technology Process of (S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)butyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

There total 11 articles about (S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)butyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 1213255-73-2
1-(hex-5-ynyl)pyrimidine-2,4(1H,3H)-dione

: 1213256-06-4
(S)-1-(1-azidobutan-2-yl)-3-(cyclopropylmethoxy)benzene

: 1213255-08-3
(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)butyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: With chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In 1,4-dioxane; at 80 ℃;
DOI:10.1021/jm3004174

Reference yield:

: C₂₀H₂₁NO₄

: 1213255-08-3
(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)butyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 5 steps

1: methanol; N,N-dimethyl-formamide / 90 °C

2: lithium borohydride / tetrahydrofuran / 0 °C

3: triethylamine / dichloromethane / 20 °C

4: sodium azide / dichloromethane; N,N-dimethyl-formamide / 60 °C

5: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,4-dioxane / 80 °C

With lithium borohydride; sodium azide; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); triethylamine; In tetrahydrofuran; 1,4-dioxane; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm3004174

Reference yield:

: C₁₅H₂₂O₄S

: 1213255-08-3
(S)-1-(4-(1-(2-(3-(cyclopropylmethoxy)phenyl)butyl)-1H-1,2,3-triazol-5-yl)butyl)pyrimidine-2,4(1H,3H)-dione

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide / dichloromethane; N,N-dimethyl-formamide / 60 °C

2: chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II) / 1,4-dioxane / 80 °C

With sodium azide; chloro(1,5-cyclooctadiene)(pentamethylcyclopentadiene)ruthenium(II); In 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm3004174