1-Benzyl-2-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid

Base Information

• Chemical Name: 1-Benzyl-2-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid
• CAS No.: 196622-20-5
• Molecular Formula: C₃₆H₂₈NO₃P
• Molecular Weight: 553.597
• Mol file: 196622-20-5.mol

Synonyms:1-Benzyl-2-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid

Chemical Property of 1-Benzyl-2-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-Benzyl-2-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid

There total 1 articles about 1-Benzyl-2-[2-(triphenyl-λ⁵-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

Methylenetriphenylphosphorane (19493-09-5) + 1-benzylindole-2,3-dicarboxylic anhydride (151054-77-2) → 1-Benzyl-2-[2-(triphenyl-λ5-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid (196622-20-5)

Guidance literature:

In tetrahydrofuran; at 0 ℃; for 1h;

DOI:10.3987/COM-97-7879

Reference yield: 74.0%

1-Benzyl-2-[2-(triphenyl-λ5-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid (196622-20-5) → 1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ5-phosphanylidene)-ethanone (196622-26-1)

Guidance literature:

With hydrogenchloride; In water; for 2h; Heating;

DOI:10.3987/COM-97-7879

Reference yield:

1-Benzyl-2-[2-(triphenyl-λ5-phosphanylidene)-acetyl]-1H-indole-3-carboxylic acid (196622-20-5) → (E)-1-(1-benzyl-3-methoxycarbonylindol-2-yl)-2-buten-1-one

Guidance literature:

Multi-step reaction with 2 steps

1: 71 percent / 2-chloro-1-methylpyridinium iodide, triethylamine / CH₂Cl₂ / 17 h

2: 31 percent / 1,3,5-trimethyl-benzene / 6 h / Heating

With 2-chloro-1-methyl-pyridinium iodide; triethylamine; In dichloromethane; 1,3,5-trimethyl-benzene;

DOI:10.3987/COM-97-7879

upstream raw materials:

Methylenetriphenylphosphorane

1-benzylindole-2,3-dicarboxylic anhydride

Downstream raw materials:

1-(1-Benzyl-1H-indol-2-yl)-2-(triphenyl-λ⁵-phosphanylidene)-ethanone