4-fluoro-N-(1-hydroxy-3,3-spirocyclopropyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

Base Information

Chemical Name:4-fluoro-N-(1-hydroxy-3,3-spirocyclopropyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide
CAS No.:1266121-68-9
Molecular Formula:C₁₇H₁₂BF₄NO₃
Molecular Weight:365.092
Hs Code.:

Synonyms:4-fluoro-N-(1-hydroxy-3,3-spirocyclopropyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

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Chemical Property of 4-fluoro-N-(1-hydroxy-3,3-spirocyclopropyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

Chemical Property:

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Technology Process of 4-fluoro-N-(1-hydroxy-3,3-spirocyclopropyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

There total 5 articles about 4-fluoro-N-(1-hydroxy-3,3-spirocyclopropyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₉H₁₀BNO₂

: 189807-21-4
2-trifluoromethyl-4-fluorobenzoyl chloride

: 1266121-68-9
4-fluoro-N-(1-hydroxy-3,3-spirocyclopropyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

Guidance literature:: With triethylamine; at 20 ℃;

Reference yield:

: 374538-03-1
2-methoxycarbonylphenylboronic acid

: 1266121-68-9
4-fluoro-N-(1-hydroxy-3,3-spirocyclopropyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 2 h / 50 °C

2.1: titanium(IV) isopropylate / tetrahydrofuran / 6.33 h / 20 °C

2.3: 48 h

3.1: nitric acid / nitrobenzene / -45 - -40 °C

4.1: palladium 10% on activated carbon / tetrahydrofuran

5.1: triethylamine / 20 °C

With titanium(IV) isopropylate; nitric acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; nitrobenzene; toluene;

Reference yield:

: 1266121-80-5
2-(2'-methoxycarbonylphenyl)-6-butyl[1,3,6,2] dioxazaborocan

: 1266121-68-9
4-fluoro-N-(1-hydroxy-3,3-spirocyclopropyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: titanium(IV) isopropylate / tetrahydrofuran / 6.33 h / 20 °C

1.3: 48 h

2.1: nitric acid / nitrobenzene / -45 - -40 °C

3.1: palladium 10% on activated carbon / tetrahydrofuran

4.1: triethylamine / 20 °C

With titanium(IV) isopropylate; nitric acid; triethylamine; palladium 10% on activated carbon; In tetrahydrofuran; nitrobenzene;