(2R,3R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

Base Information

• Chemical Name: (2R,3R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester
• CAS No.: 859235-78-2
• Molecular Formula: C₁₄H₂₀N₂O₄
• Molecular Weight: 280.324

Synonyms:(2R,3R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

Chemical Property of (2R,3R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (2R,3R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

There total 1 articles about (2R,3R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(2R,3R)-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester (859235-77-1) → (2R,3R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester (859235-78-2)

Guidance literature:

With diethylamine; In acetonitrile; at 20 ℃; for 0.666667h;

DOI:10.1002/chem.200400977

Reference yield:

(2R,3R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester (859235-78-2) → [5-sec-butyl-18-methyl-11-(2-nitro-cyclopropylmethyl)-4,7,10,13,16,20-hexaoxo-8,14-bis-(1-phenyl-ethyl)-2-propenyl-eicosahydro-3a,6,9,12,15,19-hexaaza-cyclopentacyclononadecen-17-yl]-carbamic acid 4-methyl-benzyl ester (859236-00-3)

Guidance literature:

Multi-step reaction with 5 steps

1: 0.163 g / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride; 7-aza-1-hydroxybenzotriazole; 2,4,6-trimethylpyridine / CH₂Cl₂ / 16 h / 20 °C

2: 85 percent / aq. tetra-n-butylammonium hydroxide / tetrahydrofuran / 0.75 h / 0 °C

3: 80 percent / O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium*PF₆; 7-aza-1-hydroxybenzotriazole; 2,4,6-trimethylpyridine / i-Pr₂NEt / CH₂Cl₂ / 15 h / 20 °C

4: 0.145 g / aq. HCl / ethyl acetate / 1 h / 20 °C

5: 41 mg / O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium*PF₆; 7-aza-1-hydroxybenzotriazole; i-Pr₂NEt / CH₂Cl₂ / 18 h / 20 °C

With 2,4,6-trimethyl-pyridine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; tetra(n-butyl)ammonium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1002/chem.200400977

Reference yield:

(2R,3R)-3-Amino-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester (859235-78-2) → [5-sec-butyl-18-methyl-11-(2-nitro-cyclopropylmethyl)-4,7,10,13,16,20-hexaoxo-8,14-bis-(1-phenyl-ethyl)-2-propenyl-eicosahydro-3a,6,9,12,15,19-hexaaza-cyclopentacyclononadecen-17-yl]-carbamic acid 4-methyl-benzyl ester (859236-01-4)

Guidance literature:

Multi-step reaction with 5 steps

1: 0.163 g / N'-(3-dimethylaminopropyl)-N-ethylcarbodiimide hydrochloride; 7-aza-1-hydroxybenzotriazole; 2,4,6-trimethylpyridine / CH₂Cl₂ / 16 h / 20 °C

2: 85 percent / aq. tetra-n-butylammonium hydroxide / tetrahydrofuran / 0.75 h / 0 °C

3: 80 percent / O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium*PF₆; 7-aza-1-hydroxybenzotriazole; 2,4,6-trimethylpyridine / i-Pr₂NEt / CH₂Cl₂ / 15 h / 20 °C

4: 0.145 g / aq. HCl / ethyl acetate / 1 h / 20 °C

5: 28 mg / O-(7-azabenzotriazole-1-yl)-N,N,N',N'-tetramethyluronium*PF₆; 7-aza-1-hydroxybenzotriazole; i-Pr₂NEt / CH₂Cl₂ / 18 h / 20 °C

With 2,4,6-trimethyl-pyridine; hydrogenchloride; 1-hydroxy-7-aza-benzotriazole; tetra(n-butyl)ammonium hydroxide; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; HATU; N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; dichloromethane; ethyl acetate;

DOI:10.1002/chem.200400977

upstream raw materials:

(2R,3R)-3-(9H-Fluoren-9-ylmethoxycarbonylamino)-2-(4-methyl-benzyloxycarbonylamino)-butyric acid methyl ester

Downstream raw materials:

(2S,4R)-2-[(1R,2R)-2-Methoxycarbonyl-1-methyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

(2S,4R)-2-[(1R,2R)-2-Carboxy-1-methyl-2-(4-methyl-benzyloxycarbonylamino)-ethylcarbamoyl]-4-((Z)-propenyl)-pyrrolidine-1-carboxylic acid tert-butyl ester

[5-sec-butyl-18-methyl-11-(2-nitro-cyclopropylmethyl)-4,7,10,13,16,20-hexaoxo-8,14-bis-(1-phenyl-ethyl)-2-propenyl-eicosahydro-3a,6,9,12,15,19-hexaaza-cyclopentacyclononadecen-17-yl]-carbamic acid 4-methyl-benzyl ester

[5-sec-butyl-18-methyl-11-(2-nitro-cyclopropylmethyl)-4,7,10,13,16,20-hexaoxo-8,14-bis-(1-phenyl-ethyl)-2-propenyl-eicosahydro-3a,6,9,12,15,19-hexaaza-cyclopentacyclononadecen-17-yl]-carbamic acid 4-methyl-benzyl ester

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