Tilarginine

Base Information

Chemical Name:Tilarginine
CAS No.:17035-90-4
Molecular Formula:C7H16 N4 O2
Molecular Weight:188.23
Hs Code.:
UNII:27JT06E6GR
DSSTox Substance ID:DTXSID3040560
Nikkaji Number:J264.000G
Wikipedia:Methylarginine
Wikidata:Q99615184
NCI Thesaurus Code:C1178
Pharos Ligand ID:NYZF2KPYRCWP
Metabolomics Workbench ID:43826
ChEMBL ID:CHEMBL256147
Mol file:17035-90-4.mol

Synonyms:Arginine, L-NG-Monomethyl;D-NMMA;L Monomethylarginine;L NG Monomethyl Arginine;L-Monomethylarginine;L-NG-Monomethyl Arginine;L-NMMA;N(G)-Methylarginine;N(G)-Monomethyl-D-Arginine;N(G)-Monomethylarginine;N(omega)-Monomethyl-L-Arginine;NG Monomethyl L Arginine;NG-Monomethyl-L-Arginine;omega N Methylarginine;omega-N-Methylarginine

Suppliers and Price of Tilarginine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Chem-Impex
H-Arg(Me)-OH acetate salt
100MG
$ 380.00

Chem-Impex
H-Arg(Me)-OH acetate salt
25MG
$ 195.50

American Custom Chemicals Corporation
TILARGININE 95.00%
5MG
$ 502.03

American Custom Chemicals Corporation
ARG(ME)-OH 98.00%
50MG
$ 321.30

Total 9 raw suppliers

Chemical Property of Tilarginine

Chemical Property:

Vapor Pressure:2.92E-07mmHg at 25°C
Boiling Point:392.7°Cat760mmHg
PKA:2.50±0.24(Predicted)
Flash Point:191.3°C
PSA：148.53000
Density:1.32g/cm³
LogP:0.59500
XLogP3:-4.1
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:4
Rotatable Bond Count:6
Exact Mass:188.12732577
Heavy Atom Count:13
Complexity:193

Purity/Quality:

98%Min ^*data from raw suppliers

H-Arg(Me)-OH acetate salt ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CN=C(N)NCCCC(C(=O)O)N
Isomeric SMILES:CN=C(N)NCCC[C@@H](C(=O)O)N
Recent ClinicalTrials:Phase Ib of L-NMMA and Pembrolizumab
Recent EU Clinical Trials:Effect of L-NMMA on retinal and choroidal blood flow in smokers compared to non-smokers.

Technology Process of Tilarginine

There total 13 articles about Tilarginine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2640-58-6
Nα-benzyloxycarbonyl-L-ornithine

: 17035-90-4,137694-74-7
NMMA

Guidance literature:: Multi-step reaction with 2 steps

1: 2N NaOH / 192 h / 20 °C

2: H₂ / 10percent Pd/C / methanol / 20 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1080/00397919108020795

Reference yield:

: 134810-05-2
N-α-carbobenzyloxy-N^G-methyl-(L)-arginine

: 17035-90-4,137694-74-7
NMMA

Guidance literature:: With hydrogen; palladium on activated charcoal; In methanol; at 20 ℃;
DOI:10.1080/00397919108020795

Reference yield:

: 25693-00-9
(S)-2-Amino-5-{[1-phenyl-meth-(Z)-ylidene]-amino}-pentanoic acid

: 17035-90-4,137694-74-7
NMMA

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) 1N NaOH, 2.) 1N NaOH / 1.) -3 deg C, 2.) -3 deg C

2: 2N NaOH / 192 h / 20 °C

3: H₂ / 10percent Pd/C / methanol / 20 °C

With sodium hydroxide; hydrogen; palladium on activated charcoal; In methanol;
DOI:10.1080/00397919108020795