tert-butyl (2S)-(3-hydroxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Base Information

Chemical Name:tert-butyl (2S)-(3-hydroxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate
CAS No.:334619-99-7
Molecular Formula:C₂₆H₃₈N₆O₆S
Molecular Weight:562.69
Hs Code.:

Synonyms:tert-butyl (2S)-(3-hydroxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Suppliers and Price of tert-butyl (2S)-(3-hydroxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of tert-butyl (2S)-(3-hydroxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of tert-butyl (2S)-(3-hydroxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

There total 14 articles about tert-butyl (2S)-(3-hydroxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 334619-92-0
tert-butyl (2S)-(3-acetoxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

: 334619-99-7
tert-butyl (2S)-(3-hydroxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Guidance literature:: With lithium hydroxide; In tetrahydrofuran; methanol; at 20 ℃; for 3h;
DOI:10.1016/j.bmc.2005.10.055

Reference yield:

: 451-46-7
4-fluorobenzoic acid ethyl ester

: 334619-99-7
tert-butyl (2S)-(3-hydroxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Guidance literature:: Multi-step reaction with 7 steps

1: 58 percent / (i-Pr)2NEt / 1-methyl-pyrrolidin-2-one / 20 h / 110 °C

2: 77 percent / NaOH / tetrahydrofuran; methanol; H₂O / 6 h / 40 °C

3: (i-Pr)2NEt; BOP / dimethylformamide / 14 h / 20 °C

4: H₂ / Pd/C / tetrahydrofuran / 12 h / 20 °C / 760 Torr

5: (i-Pr)2NEt / dimethylformamide / 3 h / 20 °C

6: 73 percent / LiOH / tetrahydrofuran; methanol / 3 h / 20 °C

With lithium hydroxide; sodium hydroxide; hydrogen; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.055

Reference yield:

: 34294-79-6
(S)-(-)-3-aminopiperidin-2-one

: 334619-99-7
tert-butyl (2S)-(3-hydroxypropane-1-sulfonyl)amino-3-[4-{(3S)-(pyrimidin-2-ylamino)piperidin-1-yl}benzoylamino]propionate

Guidance literature:: Multi-step reaction with 8 steps

1: LiAlH₄ / tetrahydrofuran / 5 - 20 °C

2: 42 percent / NaHCO₃ / 1-methyl-pyrrolidin-2-one / 23 h / 120 °C

3: 58 percent / (i-Pr)2NEt / 1-methyl-pyrrolidin-2-one / 20 h / 110 °C

4: 77 percent / NaOH / tetrahydrofuran; methanol; H₂O / 6 h / 40 °C

5: (i-Pr)2NEt; BOP / dimethylformamide / 14 h / 20 °C

6: H₂ / Pd/C / tetrahydrofuran / 12 h / 20 °C / 760 Torr

7: (i-Pr)2NEt / dimethylformamide / 3 h / 20 °C

8: 73 percent / LiOH / tetrahydrofuran; methanol / 3 h / 20 °C

With lithium hydroxide; sodium hydroxide; lithium aluminium tetrahydride; hydrogen; sodium hydrogencarbonate; (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine; palladium on activated charcoal; In tetrahydrofuran; 1-methyl-pyrrolidin-2-one; methanol; water; N,N-dimethyl-formamide;
DOI:10.1016/j.bmc.2005.10.055